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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Midazolam disposition in patients undergoing continuous venovenous hemodialysis.
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Midazolam disposition in patients undergoing continuous venovenous hemodialysis.

机译：接受连续静脉血液透析的患者使用咪达唑仑治疗。

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摘要

The aim of the study was to investigate the pharmacokinetics and removal of midazolam and unconjugated and glucuronidated 1-hydroxy-midazolam in 4 intensive care patients on continuous venovenous hemodialysis. Plasma midazolam and its metabolites were assessed by HPLC from blood samples collected during continuous infusion and after the end of infusion. Additional samples from the arterial and venous bloodlines and ultrafiltrate were drawn to calculate sieving coefficient and clearance of ultrafiltration. The elimination half-life of midazolam ranged from 7.6 to 22.8 hours. The clearance of ultrafiltration was between 0.13 and 4.7 ml/min and reached approximately 11% of the total clearance. The range of sieving coefficient was from 0.006 to 0.26, with an average fraction removal of 0.2%. 1-Hydroxy-midazolam glucuronide was removed by continuous hemodialysis (sieving 0.36 to 0.63), with a clearance of ultrafiltration ranging from 7.8 to 12.0 ml/min. These preliminary results showed that midazolam is not removed efficiently, and approximately half of the 1-hydroxy-midazolam glucuronide was removed by dialysis.
机译：这项研究的目的是研究连续静脉静脉血液透析对4名重症监护患者的咪达唑仑和未结合及葡萄糖醛酸化的1-羟基-咪达唑仑的药代动力学和去除作用。通过HPLC从连续输注期间和输注结束后收集的血液样品中评估血浆咪达唑仑及其代谢物。从动脉和静脉血线和超滤液中提取其他样品，以计算筛分系数和超滤清除率。咪达唑仑的消除半衰期为7.6至22.8小时。超滤的清除率在0.13至4.7 ml / min之间，约占总清除率的11％。筛分系数的范围为0.006-0.26，平均馏分去除率为0.2％。通过连续血液透析（筛分0.36至0.63）除去1-羟基-咪达唑仑葡糖醛酸，超滤清除率为7.8至12.0 ml / min。这些初步结果表明不能有效去除咪达唑仑，并且通过透析去除了大约一半的1-羟基-咪达唑仑葡糖醛酸。

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