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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Development and consequences of cannabis dependence.
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Development and consequences of cannabis dependence.

机译：大麻依赖的发展和后果。

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摘要

The past 10 to 15 years of clinical and basic research have produced strong evidence demonstrating that cannabis can and does produce dependence. Clinical and epidemiological studies indicate that cannabis dependence is a relatively common phenomenon associated with significant psychosocial impairment. Basic research has identified a neurobiological system specific to the actions of cannabinoids. Human and nonhuman studies have demonstrated a valid withdrawal syndrome that is relatively common among heavy marijuana users. Last, clinical trials evaluating treatments for cannabis dependence suggest that this disorder, like other substance dependence disorders, is responsive to intervention, yet the majority of patients have difficulty achieving and maintaining abstinence. Of concern, treatment seeking for marijuana dependence has increased almost twofold over the past 10 years. This report briefly reviews selected research literature relevant to our current understanding of cannabis dependence, its associated consequences, and treatment efficacy.
机译：在过去的10到15年的临床和基础研究中，产生了有力的证据，证明大麻可以而且确实产生了依赖性。临床和流行病学研究表明，大麻依赖是与严重的社会心理障碍相关的相对普遍的现象。基础研究已经确定了针对大麻素作用的神经生物学系统。人类和非人类研究表明，有效的戒断综合征在大量使用大麻的人中相对普遍。最后，评估大麻依赖治疗方法的临床试验表明，该疾病与其他物质依赖疾病一样，对干预反应良好，但是大多数患者难以达到和维持戒断状态。值得关注的是，在过去10年中，寻求大麻依赖的治疗几乎增加了两倍。本报告简要回顾了与我们目前对大麻依赖，其相关后果和治疗效果的了解有关的精选研究文献。

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