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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Oral hormone replacement therapy: factors that influence the estradiol concentrations achieved in a multiracial study population.
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Oral hormone replacement therapy: factors that influence the estradiol concentrations achieved in a multiracial study population.

机译：口服激素替代疗法：影响多种族研究人群中雌二醇浓度的因素。

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摘要

The assumption that estradiol (E2) concentrations are reliably increased to therapeutic levels in postmenopausal women receiving hormone replacement therapy (HRT) has not been explicitly tested. Nor have factors that may modulate the E2 levels achieved been evaluated. The author examined E2 concentrations in a multiracial study population of 309 postmenopausal women treated with oral HRT and observed that 51.1% had achieved estradiol levels of at least 45 pg/ml (achievers). The odds of being an achiever were significantly elevated among non-Caucasian women by a HRT dose greater than 0.625 mg, current moderate drinking, and increasing duration of HRT use. The odds were significantly decreased by having a high school education or less and increasing time since last HRT dose. White postmenopausal women had significantly reduced odds of being an achiever, and both a dose of less than 0.625 mg and a dose equal to 0.625 mg significantly reduced the odds of being an achiever. Increasing body mass index and menopause duration were both associated with lower odds. This report demonstrates not only that women treated with HRTdo not all achieve therapeutic levels of estradiol but also that factors can be identified that modulate the E2 concentration achieved in response to HRT administration.
机译：绝经雌激素（E2）浓度已可靠地增加到接受激素替代疗法（HRT）的绝经后妇女的治疗水平的假设尚未得到明确测试。也没有评估可能调节E2水平的因素。作者检查了309名经口服HRT治疗的绝经后妇女的多种族研究人群中的E2浓度，并观察到51.1％的雌二醇水平至少达到45 pg / ml（成就）。在非高加索女性中，HRT剂量大于0.625 mg，当前适度饮酒和使用HRT的持续时间增加，成为成功者的几率显着提高。接受高中或以下教育程度并增加自上次HRT剂量以来的时间，大大降低了几率。绝经后的白人妇女显着降低了成为成功者的几率，小于0.625 mg的剂量和等于0.625 mg的剂量均显着降低了成为成功者的几率。体重指数增加和更年期持续时间都与较低的几率相关。该报告表明，不仅接受HRT治疗的妇女均未达到雌二醇的治疗水平，而且还可以鉴定出调节HRT给药后所达到的E2浓度的因素。

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