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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Analgesic effect of sustained-release flurbiprofen administered at the site of tissue injury in the oral surgery model.
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Analgesic effect of sustained-release flurbiprofen administered at the site of tissue injury in the oral surgery model.

机译：在口腔手术模型中，在组织损伤部位施用氟比洛芬缓释剂的镇痛作用。

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摘要

Nonsteroidal anti-inflammatory drugs produce their analgesic and adverse effects through interaction with cyclooxygenase in a variety of tissues. The authors evaluated the therapeutic potential of administering a sustained-release formulation of flurbiprofen into a surgical wound following oral surgery to produce analgesia at the site of injury while minimizing exposure to potential targets for toxicity. Subjects (N = 98) received 1 of 8 treatments: flurbiprofen in a microparticle formulation in doses of 3.125 mg, 6.25 mg, 12.5 mg, 25 mg, or 50 mg; PO flurbiprofen 25 mg or 50 mg; or placebo. The flurbiprofen microparticle formulation or matching placebo was placed into the extraction sites at the end of surgery (removal of 2 lower impacted third molars). The sum of the pain visual analog scale over the 6-hour observation period demonstrated significantly less pain (P < .05) for flurbiprofen microparticle in comparison with placebo. Fewer subjects remedicated in the flurbiprofen microparticle drug groups, primarily for the 12.5-mg and higher doses. The incidence of adverse effects and local complications did not differ across groups. These data suggest that direct administration of flurbiprofen in a microparticle formulation at a site of tissue injury delays the onset and lowers the intensity of postoperative pain at lower doses than usually administered orally.
机译：非甾体类抗炎药通过与环氧化酶在多种组织中的相互作用产生镇痛作用和不良反应。作者评估了口服氟比洛芬缓释制剂在口腔手术后在伤口上产生镇痛作用而使对潜在毒性靶标的暴露最小化的治疗潜力。受试者（N = 98）接受8种治疗中的1种：微粒制剂氟比洛芬，剂量为3.125 mg，6.25 mg，12.5 mg，25 mg或50 mg; PO氟比洛芬25毫克或50毫克;或安慰剂。将氟比洛芬微粒制剂或匹配的安慰剂在手术结束时移至提取部位（去除2个下部受影响的第三磨牙）。与安慰剂相比，在6小时观察期内疼痛视觉模拟量表的总和显示氟比洛芬微粒的疼痛明显减少（P <.05）。氟比洛芬微粒药物组中接受过治疗的受试者较少，主要用于12.5毫克及更高剂量。各组的不良反应和局部并发症的发生率无差异。这些数据表明在组织损伤部位直接以微粒制剂形式施用氟比洛芬可延缓发作，并以比通常口服更低的剂量降低术后疼痛的强度。

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