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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Effect of administration time of exenatide on satiety responses, blood glucose, and adverse events in healthy volunteers.
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Effect of administration time of exenatide on satiety responses, blood glucose, and adverse events in healthy volunteers.

机译：艾塞那肽给药时间对健康志愿者的饱腹感，血糖和不良事件的影响。

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The objective was to investigate whether varying administration time of exenatide affects the magnitude of satiety responses, blood glucose, and adverse events in healthy volunteers. In this randomized, single-blind, placebo-controlled, 4-period crossover, single-dose study, the authors measured satiety responses, blood glucose, and adverse events in 20 participants receiving exenatide (10 microg) at either -60 minutes, -30 minutes, or -15 minutes or placebo at -30 minutes relative to a standardized test meal. Compared with placebo, exenatide reduced caloric intake (P = .0059), food intake (P = .0032), and glucose concentrations at 60 (P < .001) and 120 minutes after meals (P = .015). Nausea (63% vs 20%), reduced appetite (43% vs 10%), and vomiting (18% vs 0%) occurred more frequently in exenatide-treated subjects compared with placebo (P < .05). Significant differences were noted in caloric intake (P = .0149) and food intake (P = .0205) based on the administration time of exenatide, with doses given further from meals producing reduced feeding responses. No such difference was found in postprandial glucose concentrations or adverse events based on timing of exenatide administration. Single-dose exenatide administered further from mealtime had an increased magnitude on satiety responses in healthy volunteers. Postprandial glucose concentrations and the frequency of adverse events did not differ by the administration time of exenatide.
机译：目的是研究不同的艾塞那肽给药时间是否会影响健康志愿者的饱腹感，血糖和不良事件的程度。在这项随机，单盲，安慰剂对照，四周期交叉，单剂量研究中，作者测量了60分钟或60分钟接受艾塞那肽（10微克）的参与者的饱腹感，血糖和不良反应，-相对于标准测试餐，则需要30分钟或-15分钟，或者在-30分钟使用安慰剂。与安慰剂相比，艾塞那肽减少了热量摄入（P = .0059），食物摄入（P = .0032）和餐后60分钟（P <.001）和120分钟时的葡萄糖浓度（P = .015）。与安慰剂相比，在艾塞那肽治疗的受试者中恶心（63％vs 20％），食欲降低（43％vs 10％）和呕吐（18％vs 0％）的发生率更高（P <.05）。根据艾塞那肽的给药时间，热量摄入（P = .0149）和食物摄入（P = .0205）存在显着差异，进餐后进一步给予剂量会降低喂食反应。基于艾塞那肽给药的时间，在餐后葡萄糖浓度或不良事件中未发现此类差异。从进餐时间开始服用单剂量艾塞那肽对健康志愿者的饱腹感反应具有增强的作用。餐后葡萄糖浓度和不良反应的发生率随艾塞那肽的给药时间而不同。

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