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首页> 外文期刊>The Journal of dermatological treatment >Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF).
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Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF).

机译：用纳秒脉冲电场（nsPEF）治疗黑色素瘤后，在一项生存研究中，通过组织微阵列进行组织病理学随访。

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A recent study has shown that nanosecond pulsed electric fields (nsPEF) can affect the intracellular structures of melanoma within weeks. nsPEF is a non-drug, non-thermal treatment using ultrashort, intense pulsed electric fields with nanosecond durations. In the current study we followed up melanoma histopathology and metastasis with tissue micro-array 5 months post-nsPEF. After nsPEF treatment, tumor growth, tumor histology, metastasis, peri-tumor vessel and micro-vessel density were examined for the effect of nsPEF treatment on melanoma in vivo. The 17 nsPEF-treated mice were tumor-free for 169 days, significantly longer than those 19 control mice bearing melanoma without nsPEF. Histopathology follow-up showed that melanoma did not recur to the primary injection place after complete elimination. Compared with the control tumor, nsPEF-treated tumors present decreased micro-vessel density in a time-course manner in this survival study. Treatment with nsPEF caused continuous histopathological changes in melanomas, eliminated melanoma without recurrence at the primary site and prolonged animal survival time by inhibiting tumor blood supply and leading to tumor infarction. Thus, nsPEF could be applied in a non-ionizing therapeutic approach, without other agents, to locally treat tumors within a defined boundary.
机译：最近的研究表明，纳秒脉冲电场（nsPEF）可以在数周内影响黑色素瘤的细胞内结构。 nsPEF是使用纳秒持续时间的超短强脉冲电场进行的非药物，非热处理。在本研究中，我们在nsPEF后5个月采用组织微阵列对黑色素瘤的组织病理学和转移进行了随访。 nsPEF治疗后，检查肿瘤生长，肿瘤组织学，转移，肿瘤周血管和微血管密度对nsPEF治疗对体内黑色素瘤的影响。用nsPEF治疗的17只小鼠无肿瘤169天，明显长于没有nsPEF的黑色素瘤的19只对照小鼠。组织病理学随访表明，黑色素瘤完全消除后并未复发至初次注射部位。与对照肿瘤相比，在该生存研究中，nsPEF治疗的肿瘤在一定的时间过程中呈现出微血管密度降低的趋势。 nsPEF的治疗引起黑色素瘤的连续组织病理学改变，消除了黑色素瘤而未在原发部位复发，并且通过抑制肿瘤的血液供应并导致了肿瘤梗塞而延长了动物的存活时间。因此，nsPEF可以在没有其他试剂的情况下以非电离治疗方法应用，以在限定的边界内局部治疗肿瘤。

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