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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum.
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Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum.

机译：阿替洛尔在怀孕和产后的药代动力学和药效学。

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摘要

Preexisting hypertension complicates 5% of all pregnancies. The objective of this study was to evaluate steady-state atenolol pharmacokinetics and pharmacodynamics (n = 17) during the second trimester (2nd T), third trimester (3rd T), and 3 months postpartum. Pregnancy as compared to 3 months postpartum (nonpregnant control) resulted in significant (P < .05) changes, including the following: 42% (2nd T) and 50% (3rd T) increase in creatinine clearance, 38% (2nd T) and 36% (3rd T) increase in atenolol renal clearance, 12% (2nd T) and 11% (3rd T) decrease in atenolol half-life, 20% (2nd T) and 28% (3rd T) increase in cardiac output, 15% (2nd T) and 23% (3rd T) increase in resting heart rate, and 22% (2nd T) and 21% (3rd T) decrease in total peripheral resistance in subjects on steady-state oral atenolol for treatment of hypertension in pregnancy. In conclusion, the renal clearance of atenolol along with creatinine clearance is increased during pregnancy. However, this does not translate into an increase in apparent oral clearance of atenolol, possibly related to the high variability in bioavailability. Atenolol administration did not appear to change the pattern of the increase in cardiac output and the decrease in total peripheral resistance, which normally occurs during pregnancy.
机译：先前存在的高血压使所有怀孕的5％复杂化。这项研究的目的是评估妊娠中期（2nd T），妊娠中期（3rd T）和产后3个月的稳态阿替洛尔药代动力学和药效学（n = 17）。与产后3个月（未怀孕的对照）相比，怀孕导致显着（P <.05）改变，包括以下内容：肌酐清除率增加42％（第二次T）和50％（第三次T），38％（第二次T）阿替洛尔的肾清除率增加36％（3rd T），阿替洛尔半衰期减少12％（2nd T）和11％（3rd T），心输出量增加20％（2nd T）和28％（3rd T）稳态口服阿替洛尔治疗静息心率的受试者，其静息心率分别增加15％（第二次T）和23％（第三次T），总外周阻力降低22％（第二次T）和21％（第三次T）。妊娠高血压。总之，妊娠期阿替洛尔的肾清除率和肌酐清除率会增加。但是，这并不意味着阿替洛尔的表观口腔清除率增加，这可能与生物利用度的高变异性有关。阿替洛尔的给药似乎并未改变通常在怀孕期间出现的心输出量增加和总外周阻力减少的模式。

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