...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism.
【24h】

Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism.

机译：具有组胺N-甲基转移酶C314T基因多态性的健康受试者中甲基强的松龙的药效学改变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study investigated the potential differences in methylprednisolone pharmacodynamics between healthy subjects with different histamine N-methyltransferase (HNMT) C314T genotypes. Six individuals with C/C genotype and 4 with C/T genotype were administered a single intravenous dose of methylprednisolone 0.6 mg/kg ideal body weight in a randomized 2-period manner. Methylprednisolone plasma concentrations were fitted with a 1-compartment model. Cortisol and whole blood histamine suppression were assessed by indirect response models, with circadian baseline cortisol analyzed by Fourier analysis. The area between the baseline and effect curve and the area under the effect versus time curve suppression ratio were used to characterize plasma histamine suppression. Methylprednisolone pharmacokinetics and plasma and whole blood histamine suppression were similar between the 2 genotype groups. Median nadir of cortisol and the 50% inhibitory concentration for cortisol were significantly higher in subjects withC/T genotype than those with C/C genotype (P=.031 and .033, respectively, Wilcoxon rank sum test). Subjects who are heterozygous for the T314 variant allele thus appeared less sensitive to the suppressive effects of methylprednisolone on cortisol secretion.
机译：这项研究调查了具有不同组胺N-甲基转移酶（HNMT）C314T基因型的健康受试者之间甲基强的松龙药效学的潜在差异。对6名具有C / C基因型的个体和4名具有C / T基因型的个体进行了随机分2期的单次静脉内剂量的甲基强的松龙0.6 mg / kg理想体重的治疗。甲基泼尼松龙血浆浓度与1室模型拟合。皮质醇和全血组胺抑制通过间接反应模型进行评估，昼夜基线皮质醇通过傅立叶分析进行分析。基线和效应曲线之间的面积以及效应与时间曲线抑制比下的面积用于表征血浆组胺抑制。 2个基因型组之间的甲基泼尼松龙药代动力学和血浆及全血组胺抑制相似。具有C / T基因型的受试者的皮质醇中位数最低点和50％抑制皮质醇的浓度显着高于具有C / C基因型的受试者（Wilcoxon秩和检验分别为P = .031和.033）。因此，对于T314变异等位基因杂合的受试者似乎对甲基强的松龙对皮质醇分泌的抑制作用不那么敏感。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号