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Possible interaction between milnacipran and warfarin potassium

机译:米那普仑与华法林钾之间可能的相互作用

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We report a possible interaction of potential clinical significance between milnacipran and warfarin. Milnacipran is a serotonin-norepineph-rine reuptake inhibitor (SNRI) that is eliminated by direct renal excretion; it is thought to interact with the cytochrome P450 system to a minimal extent.A 53-year-old man receiving warfarin for an aortic valve replacement was admitted to Tokyo Women's Medical University, Japan, for depression; his pro-thrombin time-international normalized ratio (PT-INR) had been stabilized with warfarin 2 mg/d for many years. Milnacipran was started and increased in a stepwise fashion (Table I).
机译:我们报道了米那普仑和华法林之间可能具有潜在的临床意义的相互作用。米那普仑是一种5-羟色胺-去甲肾上腺素-再摄取抑制剂(SNRI),可通过直接肾脏排泄消除。据认为,它与细胞色素P450系统相互作用的程度很小。一名接受华法林置换主动脉瓣的53岁男子因抑郁而被日本东京女子医科大学录取。他的凝血酶原时间国际标准化比值(PT-INR)多年来用华法林2 mg / d稳定。 Milnacipran开始并逐步增加(表I)。

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