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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations
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Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations

机译：在怀孕的前三个月中接触呋喃妥因和发生严重畸形的风险

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摘要

Antibacterial drugs are among the most common medications used by pregnant women. While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nitrofurantoin during the first trimester of pregnancy have recently surfaced. To address these concerns, we conducted a large population-based retrospective cohort study to assess this possible association (including cases of medical terminations of pregnancy or stillbirth) and congenital malformations. A computerized database for medications dispensed to pregnant women in southern Israel was linked with records from the district hospital. Associations between exposure to nitrofurantoin during the first trimester and major malformations were assessed. Our research included a total of 105,492 pregnancies, 1,112 of which involved pregnancy terminations for medical reasons. A total of 1,329 infants and abortuses had been exposed to nitrofurantoin during the first trimester of pregnancy. Exposure to nitrofurantoin was not associated with increased risk of major malformations in general (adjusted OR = 0.85, 95% CI 0.67-1.08) or with specific malformations. First trimester exposure to nitrofurantoin was not associated with increased risk for total major congenital malformations or with specific malformations.
机译：抗菌药物是孕妇最常用的药物之一。尽管医学文献通常将呋喃妥因定义为可在妊娠前三个月安全使用的抗生素，但最近出现了新的担忧，即在妊娠的前三个月中接触呋喃妥因后先天畸形之间可能存在关联。为了解决这些问题，我们进行了一项基于人群的大型回顾性队列研究，以评估这种可能的关联（包括怀孕或死产的医学终止案例）和先天性畸形。以色列南部分配给孕妇的药物的计算机数据库与地区医院的记录相关联。评估了孕早期接触呋喃妥因与严重畸形之间的关联。我们的研究共计105,492例怀孕，其中1,112例因医学原因终止妊娠。在怀孕的前三个月中，共有1,329例婴儿和流产患者接受了呋喃妥因的暴露。暴露于呋喃妥因与总体上重大畸形的风险增加（校正后的OR = 0.85，95％CI 0.67-1.08）或特定畸形没有关系。孕早期暴露于呋喃妥因与总的严重先天性畸形或特定畸形的风险增加无关。

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