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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >The influence of the menstrual cycle on triazolam and indocyanine green pharmacokinetics.
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The influence of the menstrual cycle on triazolam and indocyanine green pharmacokinetics.

机译：月经周期对三唑仑和吲哚菁绿药代动力学的影响。

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摘要

The aim of this study was to investigate the effects of the menstrual cycle phase on the pharmacokinetics of two high-clearance agents, triazolam and indocyanine green (ICG). Eleven nonsmoking, healthy, eumenorrheic women were enrolled in this study. Triazolam (0.25 mg) was administered orally, and indocyanine green was administered as an i.v. bolus (0.5 mg/kg) during the follicular, ovulatory, and luteal phases of a single menstrual cycle. Blood samples were collected over 10 hours for triazolam and over 30 minutes for ICG. Triazolam and indocyanine green concentrations were quantitated by electron capture gas chromatography and spectrophotometry, respectively. Noncompartmental analysis was used to determine relevant pharmacokinetics parameters, which were statistically assessed using two-way ANOVA (p < 0.05). No statistical differences for triazolam were observed. Vd/F was lower in the luteal phase (107 L) as compared to the follicular (138 L) and ovulatory (133 L) phases. Clearance of triazolam was comparable in the follicular (583 ml/min), ovulatory (565 ml/min), and luteal (538 ml/min) phases. ICG also revealed no significant differences across the phases. These results suggest that the phases of the menstrual cycle do not influence triazolam or ICG pharmacokinetics.
机译：这项研究的目的是调查月经周期阶段对两种高清除剂三唑仑和吲哚菁绿（ICG）的药代动力学的影响。这项研究招募了11名非吸烟，健康，非出血性女性。口服给予三唑仑（0.25 mg），并以静脉注射方式给予吲哚菁绿。在一个月经周期的卵泡，排卵和黄体期推注（0.5 mg / kg）。三唑仑在10小时内收集了血液样本，ICG在30分钟内收集了血液样本。三唑仑和吲哚菁绿的浓度分别通过电子捕获气相色谱法和分光光度法定量。非房室分析用于确定相关的药代动力学参数，使用双向方差分析对其进行统计学评估（p <0.05）。没有观察到三唑仑的统计学差异。与卵泡期（138 L）和排卵期（133 L）相比，黄体期（107 L）的Vd / F较低。在卵泡期（583 ml / min），排卵期（565 ml / min）和黄体期（538 ml / min），三唑仑的清除率相当。 ICG还显示各阶段之间没有显着差异。这些结果表明，月经周期的阶段不影响三唑仑或ICG药代动力学。

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