...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Electroencephalogram effects of armodafinil: Comparison with behavioral alertness
【24h】

Electroencephalogram effects of armodafinil: Comparison with behavioral alertness

机译：阿莫达非尼的脑电图作用：与行为警觉性的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Development of central nervous system-acting drugs would be enhanced by suitable biomarkers that reflect the targeted pathophysiologic brain state.The electroencephalogram (EEG) has several characteristics of an ideal biomarker and can be promptly adapted to pre-clinical and clinical testing. Theaim of this study was to evaluate EEG as a measure of the wakefulness-promoting effect of armodafinil in sleep deprived healthy subjects. Armodafinilpharmacodynamics were simultaneously assessed by EEG- and behavioral-based measures including a well-established measure of alertness. Using twoquantitative EEG-based measures-power spectral and event-related brain activity analyses-we observed that armodafinil mitigated the slowing ofbrain activity and the decrease of the event-related brain activity caused by sleep deprivation. Armodafinil-induced changes in EEG are in agreement andexplain up to 73.1% of the armodafinil-induced changes in alertness. Our findings suggest that EEG can serve as a marker of the wakefulness-promotingdrug effect.
机译：脑电图（EEG）具有理想的生物标志物的多个特征，可以迅速地适应临床前和临床测试，这将通过反映目标病理生理脑状态的合适生物标志物来促进中枢神经系统作用药物的开发。这项研究的目的是评估脑电图作为衡量armodafinil在睡眠不足的健康受试者中清醒促进作用的一种指标。同时通过基于EEG和基于行为的措施（包括完善的警觉性措施）评估Armodafinil的药效学。使用基于脑电图的两种定量方法-功率谱和与事件相关的大脑活动分析-我们观察到阿莫达非尼减轻了因睡眠剥夺引起的大脑活动减慢和与事件相关的大脑活动的减少。 Armodafinil引起的脑电图变化是一致的，并解释了多达73.1％的armodafinil引起的机敏性变化。我们的发现表明，脑电图可以作为促觉醒药物作用的标志。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号