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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Causality of rhabdomyolysis and combined tetanus, diphtheria and acellular pertussis (tdap) vaccine administration
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Causality of rhabdomyolysis and combined tetanus, diphtheria and acellular pertussis (tdap) vaccine administration

机译：横纹肌溶解和破伤风，白喉和脱细胞百日咳（tdap）疫苗联合使用的因果关系

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摘要

In order to prevent pertussis in older populations, to reduce the potential for transmission from older individuals to susceptible infants, current recommendations are for routine immunization of adolescents, adults using reduced antigen content acellular pertussis-containing (Tdap) vaccines.[1-3] Although myalgia is common following vaccination, severe rhabdomyolysis (secondary to vaccinations alone) has only rarely been reported.[4-11] Here, we report for the first time a case of rhabdomyolysis with a very high serum creatine kinase (CK) associated with vaccination with a combined diphtheria, tetanus, and acellular pertussis (Tdap) vaccine in a patient without any other risk factors for muscle injury. An objective drug causality assessment using the Naranjo scale indicates that the rhabdomyolysis was “probable” (Score 5) causation by the Tdap vaccine.12 Presentation of rhabdomyolysis can be delayed and is fully reversible with timely treatment.
机译：为了防止老年人口中的百日咳，以减少从老年人传播到易感婴儿的可能性，目前的建议是对青少年和成人进行常规免疫，使用减少抗原含量的无细胞百日咳（Tdap）疫苗。[1-3]尽管接种疫苗后肌痛很常见，但很少报道严重的横纹肌溶解症（仅次于疫苗）。[4-11]在此，我们首次报道了横纹肌溶解症患者血清肌酸激酶（CK）非常高并伴发在没有任何其他肌肉损伤危险因素的患者中，使用白喉，破伤风和脱细胞百日咳（Tdap）联合疫苗接种。使用Naranjo量表进行的客观药物因果关系评估表明，Tdap疫苗可能导致横纹肌溶解症的病因（分数5）。12横纹肌溶解症的表现可以被延迟，并且在及时治疗的情况下是完全可逆的。

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