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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Effect of Dehusked Garcinia kola Seeds on the Overall Pharmacokinetics of Quinine in Healthy Nigerian Volunteers
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Effect of Dehusked Garcinia kola Seeds on the Overall Pharmacokinetics of Quinine in Healthy Nigerian Volunteers

机译：去壳的藤黄种子对健康尼日利亚志愿者奎宁的整体药代动力学的影响

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摘要

Weinvestigated the effect of concurrent ingestion of Garcinia kola seed on the pharmacokinetics of quinine. In a randomized crossover study, 24 healthy Nigerian volunteers were assigned into 2 groups (A and B; n = 12 per group) on the basis of G. kola dose orally ingested. Each subject received 600 mg quinine sulfate before and after ingesting 12.5 g of G. kola once daily for 7 days (group A) or 12.5 g twice daily for 6 days and once on the seventh day (group B). Blood samples were collected and analyzed for plasma quinine and its metabolite (3-hydroxyquinine) using a validated high performance liquid chromatography method. Concurrent administration of quinine with G. kola reduced quinine t(max) by 48% (group A), mean C-max by 19% and 26% in groups A and B, respectively, and slight reduction in mean AUC(0-infinity) of quinine in both groups. 3-hydroxyquinine C-max also reduced by 29% and 32%; AUC(0-infinity) by 13% and 9%, respectively. The point estimates of the T/R ratio of the geometricmeans for all C-max obtained and only the AUC(0-infinity) at a higher dose of G. kola were outside the 80%-125% bioequivalence range. In conclusion, an herb-drug interaction was noted with concurrent quinine and G. kola administration.
机译：我们调查了藤黄可乐种子同时摄入对奎宁药代动力学的影响。在一项随机交叉研究中，根据口服G. kola剂量将24名健康的尼日利亚志愿者分为2组（A和B;每组n = 12）。每个受试者在每天一次摄取12.5 g的可乐菌之前和之后和之后分别服用600 mg硫酸奎宁，持续7天（A组），或者每天两次摄取12.5 g的可乐菌，持续6天，第七天每天服用一次（B组）。收集血样，并使用经过验证的高效液相色谱法分析血浆中的奎宁及其代谢物（3-羟基奎宁）。奎宁和可乐的同时给药使A组和B组的奎宁t（max）降低48％（A组），平均C-max降低19％和26％，平均AUC（0-无穷）略有降低两组）中的奎宁。 3-羟基奎宁C-max也分别降低了29％和32％; AUC（0-infinity）分别降低了13％和9％。获得的所有C-max的几何平均值的T / R比的点估计以及仅在较高剂量的G.kola中的AUC（0-无穷大）不在80％-125％的生物等效性范围内。总之，在同时服用奎宁和可乐菌的情况下，发现了药草相互作用。

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