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首页> 外文期刊>The journal of clinical psychiatry >Nefazodone and the treatment of nonparaphilic compulsive sexual behavior: a retrospective study.
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Nefazodone and the treatment of nonparaphilic compulsive sexual behavior: a retrospective study.

机译：奈法唑酮与非亲友性强迫性行为的治疗：一项回顾性研究。

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BACKGROUND: Recent reports suggest that individuals with nonparaphilic compulsive sexual behavior can be treated pharmacologically with selective serotonin reuptake inhibitors (SSRIs) to control sexual obsessions and compulsions. However, these medications have produced sexual side effects that may limit long-term use, particularly as individuals strive to reestablish healthy sexual relationships. Nefazodone is an antidepressant that is not associated with the sexual side effects of other SSRIs. We examined retrospective data from our clinic to investigate whether nefazodone has utility in the treatment of nonparaphilic compulsive sexual behavior. METHOD: Fourteen subjects who met DSM-IV criteria for sexual disorder NOS as well as criteria used by our research group for nonparaphilic compulsive sexual behavior and who had been treated with nefazodone were selected from patient charts at our clinic. The treating physician abstracted information from the charts regarding comorbid psychiatric conditions, medication, dosage, treatment response, and side effects. RESULTS: In this study, the mean dosage of nefazodone was 200 mg/day. Of the subjects who remained on long-term nefazodone therapy, 6 (55%) reported good control of sexual obsessions and compulsions, and 5 (45%) reported a remission of sexual obsessions and compulsions. CONCLUSION: Results from this preliminary retrospective study suggest that nefazodone decreases the frequency of sexual obsessions and compulsions but does not produce the undesired sexual side effects caused by SSRI treatment.
机译：背景：最近的报道表明，具有非亲友性强迫性行为的个体可以通过选择性5-羟色胺再摄取抑制剂（SSRI）进行药理治疗，以控制性痴迷和强迫行为。但是，这些药物产生的性副作用可能会限制长期使用，尤其是当个人努力重建健康的性关系时。奈法唑酮是一种抗抑郁药，与其他SSRI的性副作用无关。我们检查了来自我们诊所的回顾性数据，以调查奈法唑酮是否可用于治疗非亲友性强迫性行为。方法：从我们诊所的患者病历表中选出14名符合DSM-IV性疾病NOS标准以及我们研究小组用于非副性强迫性行为的标准并接受奈法唑酮治疗的受试者。主治医师从图表中提取出有关合并症的精神疾病，用药，剂量，治疗反应和副作用的信息。结果：在这项研究中，奈法唑酮的平均剂量为200 mg / day。在长期接受奈法唑酮治疗的受试者中，有6名（55％）报告称对性强迫症和性强迫症的控制良好，有5名（45％）报告称对性强迫症和性欲的缓解。结论：该初步回顾性研究的结果表明，奈法唑酮可减少性痴迷和强迫症的发生频率，但不会产生SSRI治疗引起的不良性副作用。

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