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Pharmacologic characteristics of ideal antidepressants in the 21st century.

机译:理想抗抑郁药在21世纪的药理特性。

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摘要

The availability of drugs for use as antidepressants has expanded greatly in the past 2 decades. Not only has the number of drugs increased but so has the diversity in associated pharmacologic effects. Drug development for central nervous system agents is proceeding at an accelerated pace. The coming decades hold the promise for the introduction of newer antidepressants that have novel mechanisms of action, improved adverse event profiles, and expanded indications. Unfortunately, the ideal antidepressant is yet to be formulated. Pharmacologic characteristics for desirable improvements are discussed relative to the currently available drugs.
机译:在过去的20年中,用作抗抑郁药的药物的供应量大大增加。不仅药物数量增加了,而且相关药理作用的多样性也增加了。用于中枢神经系统药物的药物开发正在加速进行。在未来的几十年中,有望引入具有新型作用机制,改善的不良事件和扩大适应症的新型抗抑郁药。不幸的是,理想的抗抑郁药尚未配制。相对于当前可用的药物,讨论了期望改善的药理学特征。

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