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首页> 外文期刊>The journal of clinical psychiatry >The role of novel antipsychotics in bipolar disorders.
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The role of novel antipsychotics in bipolar disorders.

机译：新型抗精神病药在躁郁症中的作用。

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摘要

Patients with bipolar disorder frequently receive antipsychotic agents during both the acute and maintenance phases of treatment. Conventional antipsychotics are effective against mania, but they may induce depressive symptoms and expose patients with bipolar disorder to increased risks of tardive dyskinesia. Recent studies have shown risperidone to be effective for acute mania, both as monotherapy and in combination with mood stabilizers; this agent has also shown efficacy as add-on maintenance therapy in open-label studies as it exhibited both antimanic and antidepressant effects. Olanzapine, another novel antipsychotic, is also effective against both manic and depressive symptoms and in the maintenance treatment as indicated by an open-label study. Data on other novel agents are more limited.
机译：躁郁症患者在治疗的急性期和维持期均经常接受抗精神病药治疗。常规抗精神病药可有效对抗躁狂症，但它们可能诱发抑郁症状并使躁郁症患者面临迟发性运动障碍的风险增加。最近的研究表明，利培酮作为单一疗法或与情绪稳定剂联合使用对急性躁狂有效。该药物还显示出抗躁狂和抗抑郁作用，因此在开放标签研究中也显示出作为补充维持疗法的功效。如开放标签研究所示，另一种新型抗精神病药物奥氮平也可有效抵抗躁狂和抑郁症状，并在维持治疗方面有效。有关其他新型药物的数据更为有限。

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