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首页> 外文期刊>The journal of clinical psychiatry >Paroxetine levels in postpartum depressed women, breast milk, and infant serum.
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Paroxetine levels in postpartum depressed women, breast milk, and infant serum.

机译：产后抑郁妇女，母乳和婴儿血清中的帕罗西汀水平。

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BACKGROUND: The purpose of this study was to determine the concentrations of paroxetine in maternal serum, breast milk, and infant serum samples and to estimate infant exposure through breastfeeding. METHOD: A total of 25 sample sets was obtained: I sample set each from 23 mother-infant dyads and 2 sample sets from 1 mother-infant dyad. All mothers met DSM-IV criteria for major depressive disorder. The maternal fixed dosage of paroxetine was 10, 20, or 40 mg/day for a minimum of 30 days before the samples were drawn. Samples were collected 6 hours after dose intake, and the concentration of paroxetine in each sample was determined using gas chromatography/mass spectrometry. The analytic method employed in this study is the most sensitive to date, with the ability to detect drug concentrations as low as 0.1 ng/mL. RESULTS: Detectable levels of paroxetine were present in all maternal serum samples and in 24 of the 25 breast milk samples. In all of the infant serum samples, the paroxetine concentrations were below the lower limit of quantification. No unusual adverse effects were reported in any of the infants. CONCLUSION: The results of this study demonstrate that paroxetine, like the other selective serotonin reuptake inhibitors studied to date, is excreted into the breast milk of nursing mothers. The mean infant dose of paroxetine was 1. 1% of the maternal dose. Although no short-term adverse effects were reported in any of the infants in this study, future studies are needed to address a more systematic method for observing and recording any adverse effects. In addition, future studies should incorporate follow-up studies in order to evaluate possible long-term effects of paroxetine exposure.
机译：摘要背景：这项研究的目的是确定母体血清，母乳和婴儿血清样品中帕罗西汀的浓度，并估计通过母乳喂养婴儿的暴露量。方法：总共获得25个样本集：我分别从23个母婴双胞胎样本组和2个样本组（来自1个母婴双胞胎样本组）中抽取了一组样本。所有母亲均符合重度抑郁症的DSM-IV标准。在抽取样本之前，帕罗西汀的孕妇固定剂量为10、20或40 mg / day，持续至少30天。剂量摄入后6小时收集样品，并使用气相色谱/质谱法测定每个样品中帕罗西汀的浓度。这项研究中使用的分析方法是迄今为止最敏感的方法，能够检测低至0.1 ng / mL的药物浓度。结果：所有孕妇血清样品和25份母乳样品中的24份中均存在可检测到的帕罗西汀水平。在所有婴儿血清样品中，帕罗西汀的浓度均低于定量下限。在任何婴儿中均未报告异常的不良反应。结论：这项研究的结果表明，帕罗西汀像迄今为止研究的其他选择性5-羟色胺再摄取抑制剂一样，被排泄到哺乳母亲的母乳中。婴儿的帕罗西汀平均剂量为产妇剂量的1. 1％。尽管在本研究中未报告任何婴儿的短期不良反应，但仍需要进行进一步的研究以观察和记录不良反应的更系统的方法。此外，未来的研究应包括随访研究，以评估帕罗西汀暴露的长期影响。

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