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首页> 外文期刊>The journal of clinical psychiatry >Sexual functioning and SSRIs.
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Sexual functioning and SSRIs.

机译：性功能和SSRI。

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This article reviews the literature concerning the relationship between sexual functioning and selective serotonin reuptake inhibitors (SSRIs). Reduced sexual functioning is a common depressive symptom that typically improves after successful antidepressant treatment. On the other hand, sexual dysfunction has been observed in a substantial proportion of patients treated with all classes of antidepressants. In particular, SSRI use has been shown to be associated with sexual dysfunction. A number of pharmacologic interventions have been found to be helpful in anecdotal case reports. Unfortunately, the lack of placebo-controlled studies in this area limits our ability to draw firm conclusions on the efficacy of such interventions. Three classes of drugs have primarily been used to counteract sexual side effects of SSRIs: serotonin receptor antagonists, a2-adrenergic receptor antagonists, and dopaminergic agents. An open trial from our group suggests the potential usefulness of oral sildenafil in the treatment of antidepressant-associated sexual side effects, but further studies are needed.
机译：本文回顾了有关性功能与选择性5-羟色胺再摄取抑制剂（SSRIs）之间关系的文献。性功能下降是常见的抑郁症状，通常在成功进行抗抑郁治疗后会改善。另一方面，在使用所有抗抑郁药治疗的患者中，有相当一部分观察到性功能障碍。特别是，已显示SSRI的使用与性功能障碍有关。已发现许多药理学干预措施有助于轶事病例报告。不幸的是，在这一领域缺乏安慰剂对照研究限制了我们对此类干预措施的有效性得出可靠结论的能力。三类药物主要用于抵消SSRI的性副作用：5-羟色胺受体拮抗剂，α2-肾上腺素能受体拮抗剂和多巴胺能药物。我们小组的一项公开试验表明，口服西地那非在治疗抗抑郁药相关的性副作用方面具有潜在的作用，但还需要进一步的研究。

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