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首页> 外文期刊>The journal of clinical psychiatry >Conventional antipsychotic prescription in unipolar depression, I: an audit and recommendations for practice.
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Conventional antipsychotic prescription in unipolar depression, I: an audit and recommendations for practice.

机译：单相抑郁症的常规抗精神病药方，I：审核和实践建议。

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BACKGROUND: Despite narrow indications for conventional antipsychotics in depression, recent reports confirm a suspicion that they are widely prescribed in nonpsychotic depressive conditions. METHOD: Data from the case notes of over 510 patients with unipolar depression (unvalidated clinical diagnoses) were collected between June 1997 and January 1998 from community and acute units in 1 National Health Service (NHS) Trust. The aim of this audit was to assess the extent and pattern of antipsychotic prescription in this sample. RESULTS: More than a quarter (N = 138) of the sample (N = 494) were currently prescribed an antipsychotic; 40% of these received an antipsychotic without any recognized indication. The mean time on antipsychotic therapy was 3 years. Patients on antipsychotic therapy were, on average, taking twice as many total medications as those not on antipsychotic therapy. Patients with psychotic depression were taking an average of nearly twice the antipsychotic dose of nonpsychotic patients.CONCLUSION: Current clinical guidelines commend careful antidepressant choice in preference to polypharmacy. A number of drug choices for specific depressive presentations are summarized from recent sources.
机译：背景：尽管在抑郁症中常规抗精神病药的适应症狭窄，但最近的报道证实了人们怀疑在非精神病性抑郁症患者中广泛使用这些药物的怀疑。方法：1997年6月至1998年1月之间，从1个美国国家卫生服务（NHS）基金会的社区和急诊科收集了510例单相抑郁症患者的病例记录数据。该审核的目的是评估该样本中抗精神病药处方的范围和模式。结果：目前有超过四分之一（N = 138）的样本（N = 494）被处方为抗精神病药;其中40％的人接受了抗精神病药治疗而没有任何公认的适应症。抗精神病治疗的平均时间为3年。平均而言，接受抗精神病药物治疗的患者服用的总药物量是未接受抗精神病药物治疗的患者的两倍。精神病性抑郁症患者平均服用的抗精神病药物剂量约为非精神病性患者的两倍。结论：目前的临床指南推荐谨慎选择抗抑郁药，而不是综合药物。从最近的资料中总结了用于特定抑郁症表现的多种药物选择。

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