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首页> 外文期刊>The journal of clinical psychiatry >Relapse and rehospitalization: comparing oral and depot antipsychotics.
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Relapse and rehospitalization: comparing oral and depot antipsychotics.

机译：复发和再次住院：比较口服和长效抗精神病药。

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A review of studies that compared conventional oral and depot antipsychotic medications highlighted the following points. Mirror-image studies in which patients served as their own controls provided evidence of substantial benefit for depot injectable medications. The randomized clinical trials did not, in general, support the findings of significant decrease in relapse rates between these 2 routes of administration. Across the studies reviewed, the 1-year relapse rate for long-acting depot medication was 27% compared with 42% for patients who received oral medication. The 27% risk of relapse in patients who received guaranteed depot medication suggests that relapse is not always driven by noncompliance. In the only study that lasted for 2 years, the risk of relapse decreased substantially in the depot-treated patients, suggesting that risk of noncompliance may be a more important factor in relapse over extended periods of time. A recent formal meta-analytic review of depot medications concluded that this route of administration resulted in clinical advantages in terms of global outcome.
机译：一项比较常规口服和长效抗精神病药物研究的综述强调了以下几点。以患者作为自己的对照的镜像研究提供了可注射长效药物的实质性好处的证据。通常，随机临床试验不支持这两种给药途径之间复发率显着降低的发现。在回顾的所有研究中，长效长效药物的1年复发率为27％，而口服药物的患者为42％。接受有保证的库房用药的患者发生复发的风险为27％，这表明复发并不总是由违规引起的。在仅持续2年的唯一研究中，接受储库治疗的患者复发的风险大大降低，这表明不依从的风险可能是长时间内复发的更重要因素。最近对储库用药进行的正式荟萃分析总结认为，这种给药途径在整体疗效方面具有临床优势。

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