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首页> 外文期刊>The journal of clinical psychiatry >Magnetic Resonance Spectroscopy Studies of GABA in Neuropsychiatric Disorders.
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Magnetic Resonance Spectroscopy Studies of GABA in Neuropsychiatric Disorders.

机译：神经精神疾病中GABA的磁共振波谱研究。

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摘要

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and is integral to managing brain excitability. GABA concentrations vary according to age, gender, and brain region. Magnetic resonance spectroscopy (MRS), with editing or with localized 2-dimensional chemical shift methods, can measure GABA levels in vivo, ex vivo, or in vitro, particularly at ultra-high magnetic field strengths. Proton ((1)H) MRS studies have found reduced or abnormal GABA concentrations in several neuropsychiatric disorders, including epilepsy, anxiety disorders, major depression, and drug addiction. Disorders with low GABA levels may be treated by augmentation of GABAergic function, such as by medications that block the degradation or reuptake of GABA. Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder.
机译：γ-氨基丁酸（GABA）是中枢神经系统中主要的抑制性神经递质，对控制脑部兴奋性至关重要。 GABA浓度随年龄，性别和大脑区域的不同而不同。具有编辑或局部二维化学位移方法的磁共振波谱（MRS）可以在体内，离体或体外测量GABA水平，尤其是在超高磁场强度下。质子（（1）H）MRS研究发现，几种神经精神疾病包括癫痫，焦虑症，重度抑郁和药物成瘾，GABA浓度降低或异常。低GABA水平的疾病可以通过增强GABA能功能来治疗，例如通过阻断GABA降解或再摄取的药物来治疗。这种合理的治疗方法的例子包括提高脑GABA水平并有效治疗癫痫和焦虑症的抗惊厥药。

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