...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >A Survey of Reports of Quetiapine-Associated Hyperglycemia and Diabetes Mellitus.
【24h】

A Survey of Reports of Quetiapine-Associated Hyperglycemia and Diabetes Mellitus.

机译：喹硫平相关的高血糖和糖尿病的报告调查。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To explore the clinical characteristics of hyperglycemia in patients treated with quetiapine. METHOD: A pharmacovigilance survey of spontaneously reported adverse events in quetiapine-treated patients was conducted using reports from the U.S. Food and Drug Administration MedWatch program (January 1, 1997, through July 31, 2002) and published cases using the search terms hyperglycemia, diabetes, acidosis, ketosis, and ketoacidosis. RESULTS: We identified 46 reports of quetiapine-associated hyperglycemia or diabetes and 9 additional reports of acidosis that occurred in the absence of hyperglycemia and were excluded from the immediate analyses. Of the reports of quetiapine-associated hyperglycemia, 34 patients had newly diagnosed hyperglycemia, 8 had exacerbation of preexisting diabetes mellitus, and 4 could not be classified. The mean +/- SD age was 35.3 +/- 16.2 years (range, 5-76 years). New-onset patients (aged 31.2 +/- 14.8 years) tended to be younger than those with preexisting diabetes (43.5 +/- 16.4 years, p =.08). The overall male:female ratio was 1.9. Most cases appeared within 6 months of quetiapine initiation. The severity of cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma. There were 21 cases of ketoacidosis or ketosis. There were 11 deaths. CONCLUSION: Atypical antipsychotic use may unmask or precipitate hyperglycemia. UPDATE: An additional 23 cases were identified since August 1, 2002, the end of the first survey, by extending the search through November 30, 2003, bringing the total to 69.
机译：目的：探讨喹硫平治疗患者高血糖的临床特点。方法：使用美国食品药品监督管理局MedWatch计划（1997年1月1日至2002年7月31日）的报告进行喹硫平治疗患者自发报告的不良事件的药物警戒调查，并使用搜索词高血糖，糖尿病公布病例，酸中毒，酮症和酮症酸中毒。结果：我们确定了46例喹硫平相关的高血糖或糖尿病的报告，以及9例在没有高血糖的情况下发生的酸中毒的报告，这些被排除在即时分析之外。在喹硫平相关的高血糖的报告中，新诊断为高血糖的34例患者，已有的糖尿病加重的8例，无法分类的4例。 +/- SD平均年龄为35.3 +/- 16.2岁（范围5-76岁）。新发病例（31.2 +/- 14.8岁）往往比先前患有糖尿病的患者（43.5 +/- 16.4岁，p = .08）年轻。男女总比例为1.9。大多数病例在喹硫平启动后6个月内出现。病例的严重程度从轻度葡萄糖耐受不良到糖尿病性酮症酸中毒或高渗性昏迷。酮症酸中毒或酮症21例。有11人死亡。结论：非典型抗精神病药的使用可能会掩盖或加剧高血糖症。更新：自2002年8月1日（第一次调查结束）以来，通过将搜索范围扩展到2003年11月30日，又发现了23个案例，总数达到了69个。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号