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首页> 外文期刊>The journal of clinical psychiatry >Single-dose intravenous valproate in acute mania.
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Single-dose intravenous valproate in acute mania.

机译：急性躁狂症的单剂量静脉丙戊酸盐。

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OBJECTIVE: High-dose loading with oral and intravenous valproate has been reported to be therapeutic in mania over 48 to 72 hours. We hypothesized that very high dose intravenous (IV) valproate might have even more rapid effects equivalent to effects in status epilepticus that occur within 20 minutes. METHOD: Seven patients with mania (Young Mania Rating Scale score > 20) and minimal prior drug treatment were given valproate 20 mg/kg IV over 30 minutes. RESULTS: No antimanic effects were observed during 120 minutes of observation. There were no side effects. CONCLUSION: Slowly evolving biochemical changes, perhaps at the gene level, may be required for the antimanic effect of anticonvulsants.
机译：目的：口服和静脉注射丙戊酸盐大剂量负荷治疗躁狂症有48至72小时的疗效。我们假设非常高剂量的丙戊酸盐静脉注射（IV）可能具有更快的效果，等同于在20分钟内发生的癫痫持续状态。方法：7名躁狂症患者（年轻躁狂症评定量表评分> 20）且在用药最少之前接受了丙戊酸20 mg / kg静脉输注，疗程30分钟。结果：在120分钟的观察中未观察到抗躁狂作用。没有副作用。结论：可能需要在基因水平上缓慢发展的生化变化才能发挥抗惊厥药的抗躁狂作用。

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