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首页> 外文期刊>The journal of clinical psychiatry >Serotonin Function, Personality-Trait Variations, and Childhood Abuse in Women With Bulimia-Spectrum Eating Disorders.
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Serotonin Function, Personality-Trait Variations, and Childhood Abuse in Women With Bulimia-Spectrum Eating Disorders.

机译：患有贪食症频谱饮食失调的妇女的5-羟色胺功能，性格特质变异和童年滥用。

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BACKGROUND: Across populations, findings associate impulsivity, behavioral disinhibition, or hostility with reduced central serotonin (5-hydroxytryptamine: 5-HT) activity and increased likelihood of childhood abuse. Inconsistently, findings associate compulsivity, behavioral inhibition, or anxiousness with elevated 5-HT neurotransmission. We explored relationships among measures of 5-HT system functioning, behavioral inhibition/disinhibition, and childhood abuse in women with bulimia-spectrum eating syndromes. METHOD: In 73 bulimic (body mass index [kg/m(2)] under 30, binge eating at least once weekly) and 50 normal-eater control women, we obtained indices of platelet paroxetine binding and 5-HT agonist (m-CPP)-stimulated neuroendocrine responses. Cluster analysis was used to classify the bulimic women according to 5-HT "profiles." Resulting groups were then compared on symptom and trait measures. RESULTS: Measures of paroxetine-binding density (B(max)) and affinity (K(d)) contributed significantly (p <.001 and p <.02, respectively) to a classification of bulimic women into groups with "low density/high affinity" (N = 52) or high density/low affinity classification did not predict eating-symptom severity. However, the "high density" pattern was associated with increased perfectionism and compulsivity, reduced risk of childhood sexual abuse, and (to some extent) reduced probability of borderline personality disorder. DISCUSSION: In women with bulimic syndromes, serotonergic factors, personality-trait variations, and developmental typologies converge in principled fashion. Our findings corroborate (with neurobiological evidence) the concept of underregulated and overregulated subtypes within the bulimic population.
机译：背景：在整个人群中，研究结果将冲动，行为抑制或敌意与中枢5-羟色胺（5-羟色胺：5-HT）活性降低和儿童虐待的可能性增加相关。不一致的是，研究结果将强迫性，行为抑制或焦虑与5-HT神经传递升高联系起来。我们探讨了5-HT系统功能，行为抑制/解除抑制和贪食症-频谱饮食综合征妇女童年虐待之间的关系。方法：在73名暴食（体重指数[kg / m（2）]在30岁以下，暴饮暴食至少每周一次）和50例饮食正常的对照女性中，我们获得了血小板帕罗西汀结合和5-HT激动剂（m- CPP）刺激的神经内分泌反应。聚类分析用于根据5-HT“特征”对暴食妇女进行分类。然后比较结果组的症状和特征量度。结果：帕罗西汀结合密度（B（max））和亲和力（K（d））的测量显着地（分别为p <.001和p <.02）导致将暴食女性分为“低密度/高亲和力”（N = 52）或高密度/低亲和力分类不能预测进食症状的严重程度。但是，“高密度”模式与完美主义和强迫性的增加，儿童期性虐待的风险降低以及（在某种程度上）边界人格障碍的可能性降低相关。讨论：在患有脓毒症综合征的女性中，血清素能因素，人格特质变异和发育类型学以有原则的方式融合。我们的发现证实了（根据神经生物学证据）暴食人群中亚型被过度调节和过度调节的概念。

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