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首页> 外文期刊>The journal of clinical psychiatry >Sex differences in depressed substance abusers.
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Sex differences in depressed substance abusers.

机译：抑郁药物滥用者的性别差异。

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OBJECTIVE: The main goal of this article is to highlight gender-specific differences in the epidemiology, clinical nature, and treatment responses of comorbid depression and substance abuse. The second goal is to make recommendations for future research in the area of gender-specific aspects of comorbid depression and substance abuse. DATA SYNTHESIS: A literature review was conducted using the keywords sex, gender, depression, and substance use disorders for the time period 1980 to the present. We first outline the well-known sex differences in the epidemiology of depressed substance abusers and discuss the clinical significance of substance abuse in depression. Two distinct ways of understanding the role of substance abuse in depression are presented. The first is the role that depression may play in escalation of substance use, and the second is depression as a common sequela of chronic substance abuse. These 2 manifestations that are not mutually exclusive, often co-occurring in female substance abusers, have important treatment implications. Research on treatment response for the above clinical presentations is discussed followed by a summary of the factors that may influence sex differences in the association between depression and substance abuse. CONCLUSION: Recommendations for future research examining sex differences in animal models of depression, substance abuse, and therapeutic response to medications were made. The need for gender-specific clinical research on the association between depression, stress, and substance abuse is also highlighted.
机译：目的：本文的主要目的是强调流行病学，临床性质以及合并抑郁症和药物滥用的治疗反应方面的性别差异。第二个目标是为合并抑郁症和药物滥用的特定性别方面的研究提出建议。数据综合：使用关键词性别，性别，抑郁和药物滥用障碍进行了文献综述，时间范围为1980年至今。我们首先概述了抑郁症药物滥用者流行病学中众所周知的性别差异，并讨论了抑郁症药物滥用的临床意义。介绍了两种不同的理解药物滥用在抑郁症中作用的方法。第一个是抑郁症在药物滥用升级中可能扮演的角色，第二个是抑郁症是慢性药物滥用的常见后遗症。这两种不互斥的表现通常在女性吸毒者中同时出现，对治疗有重要意义。讨论了上述临床表现的治疗反应研究，然后总结了可能影响抑郁症与药物滥用之间的性别差异的因素。结论：为今后研究抑郁症，药物滥用和对药物的治疗反应的动物模型中的性别差异提出了建议。还强调了针对性别的临床研究，涉及抑郁症，压力和药物滥用之间的关系。

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