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首页> 外文期刊>The journal of clinical psychiatry >Efficacy and effectiveness of first- and second-generation antipsychotics in schizophrenia.
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Efficacy and effectiveness of first- and second-generation antipsychotics in schizophrenia.

机译：第一代和第二代抗精神病药在精神分裂症中的疗效和有效性。

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While efficacy as a concept is concerned with whether a treatment works under ideal conditions, effectiveness is concerned with whether a treatment works under the conditions of routine care. Large-scale clinical, pharmacy, and administrative databases can provide naturalistic data for effectiveness studies when appropriate methodology is employed. The Nathan Kline Institute Integrated Research Database includes patient-specific admission, demographic, diagnostic, medication, and discharge information from hospitals operated by the New York State Office of Mental Health. This database was used to study the effectiveness of first- versus second-generation antipsychotics in the treatment of schizophrenia and schizoaffective disorder. Switching off the index medication regimen prior to discharge (negative outcome) was our principal outcome of interest. We concluded that, as a class, second-generation antipsychotics were less likely than first-generation agents to be associated with premature discontinuation of an antipsychotic regimen, both when used as the initial medication regimen following hospitalization and as the second regimen following a prior medication switch.
机译：有效性作为一个概念与治疗是否在理想条件下有效有关，而有效性与治疗是否在常规护理条件下有效有关。当采用适当的方法时，大规模的临床，药学和行政数据库可以为有效性研究提供自然的数据。内森·克莱因研究所综合研究数据库包含纽约州心理健康办公室运营的医院的患者特定入院，人口统计学，诊断，药物和出院信息。该数据库用于研究第一代和第二代抗精神病药在精神分裂症和精神分裂症治疗中的有效性。出院前关闭索引药物治疗方案（阴性结果）是我们关注的主要结果。我们得出结论，作为一类，第二代抗精神病药比第一代药物更容易与抗精神病药的过早停用相关联，无论是用作住院后的初始药物治疗还是先前服药后的第二种治疗开关。

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