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首页> 外文期刊>The journal of clinical psychiatry >A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients.
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A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients.

机译：氟哌利多对严重躁动和暴力患者快速镇静的安全性和有效性的综述。

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BACKGROUND: Droperidol had become a standard treatment for sedating severely agitated or violent patients in both psychiatric and medical emergency departments. However, several recent articles have suggested that droperidol may have a quinidine-like effect similar to that of thioridazine in inducing dysrhythmia. METHOD: In view of the recent U.S. Food and Drug Administration (FDA) position regarding the use of thioridazine, the authors reviewed the literature regarding droperidol and dysrhythmia in a MEDLINE search for the years 1960-2002 using the search terms droperidol, dysrhythmia, QTc interval, and sudden death as well as their own experience in using droperidol in a busy psychiatric emergency department. This review was done before the FDA's very recent and peremptory warning about droperidol. RESULTS: The authors report that, in treating approximately 12,000 patients over the past decade, they have never experienced a clinically significant adverse dysrhythmic event using droperidol to sedate severely agitated or violent patients. CONCLUSION: The authors conclude that, in clinical practice, droperidol is an extremely effective and safe method for treating severely agitated or violent patients. While in theory droperidol may prolong the QT interval to an extent similar to thioridazine, in clinical use there is no pattern of sudden deaths analogous to those that provoked the FDA warning about thioridazine.
机译：背景：氟哌利多已成为镇静和精神病急症患者镇静或暴力患者镇静的标准治疗方法。然而，最近的几篇文章提示，氟哌啶醇在诱导心律不齐方面可能具有类似于硫代哒嗪的奎尼丁样作用。方法：鉴于最近美国食品和药物管理局（FDA）关于使用硫代哒嗪的立场，作者使用检索词droperidol，dysrhythmia，QTc在1960-2002年的MEDLINE搜索中回顾了有关droperidol和心律失常的文献间隔，突然死亡以及自己在繁忙的精神病急诊科使用氟哌利多的经验。这项审查是在FDA有关氟哌利多的最新强制性警告之前进行的。结果：作者报告说，在过去十年中，在治疗约12,000名患者中，他们从未经历过使用氟哌啶醇镇定剧烈躁动​​或暴力患者的临床重大不良心律失常事件。结论：作者得出结论，在临​​床实践中，氟哌利多是治疗严重躁动或暴力患者的极其有效和安全的方法。尽管从理论上说，氟哌利多可以延长QT间隔至与硫代哒嗪相似的程度，但在临床应用中，没有像FDA引起硫代哒嗪警告那样的猝死模式。

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