...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Newer anticonvulsants: dosing strategies and cognition in treating patients with mood disorders and epilepsy.
【24h】

Newer anticonvulsants: dosing strategies and cognition in treating patients with mood disorders and epilepsy.

机译：新型抗惊厥药：治疗情绪障碍和癫痫患者的给药策略和认知。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Anticonvulsants are employed to treat a variety of disorders. The most common adverse side effects of anticonvulsants are mediated via the central nervous system. Examples include sedation, dizziness, psychomotor slowing, and impairment of attention, memory, and other cognitive functions. Since multiple new anticonvulsants have been introduced in recent years, the question arises as to the frequency and magnitude of their cognitive side effects. METHODS: Experimental design flaws in assessing the cognitive effects of anticonvulsants were reviewed. A MEDLINE search of the medical literature was conducted, cross-referencing terms related to cognition and anticonvulsants. Research articles were selected based on their relevance to the topic and adherence to methodological criteria. RESULTS: Incomplete information is available on the new anticonvulsants, but the present data suggest that some of the newer anticonvulsants possess favorable cognitive profiles. Also, the importance of dosing regimens and titration speed at drug initiation is discussed. CONCLUSION: All anticonvulsants possess some cognitive side effects, but differential effects can be seen. The cognitive effects of several newer anticonvulsants have been examined, but additional studies are needed to fully establish the cognitive effects of these agents. Dosage, titration rate at initiation, comedications, individual sensitivity, and underlying disease processes may influence cognitive side effects. Understanding these factors is important to maximize the benefits of anticonvulsant therapy. Cognitive side effects are one of the factors that physicians should consider in drug choice and monitoring of their patients.
机译：背景：抗惊厥药被用于治疗多种疾病。抗惊厥药最常见的不良副作用是通过中枢神经系统介导的。例子包括镇静，头晕，精神运动减慢，注意力，记忆力和其他认知功能受损。由于近年来已经引入了多种新的抗惊厥药，因此出现了关于其认知副作用的频率和程度的问题。方法：评估抗惊厥药的认知效果的实验设计缺陷。进行MEDLINE医学文献搜索，交叉引用与认知和抗惊厥相关的术语。根据研究主题与主题的相关性以及对方法标准的遵守程度来选择研究文章。结果：关于新的抗惊厥药尚不完整的信息，但目前的数据表明一些较新的抗惊厥药具有良好的认知特征。此外，还讨论了给药方案和药物启动时滴定速度的重要性。结论：所有抗惊厥药都有一定的认知副作用，但可以看到不同的作用。已经检查了几种新型抗惊厥药的认知作用，但是还需要进行其他研究才能完全确定这些药物的认知作用。剂量，开始时的滴定速率，喜剧，个人敏感性和潜在的疾病过程可能会影响认知副作用。了解这些因素对于最大化抗惊厥治疗的益处非常重要。认知副作用是医师在选择药物和监测患者时应考虑的因素之一。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号