...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Psychosis in Mania: Specificity of Its Role in Severity and Treatment Response.
【24h】

Psychosis in Mania: Specificity of Its Role in Severity and Treatment Response.

机译：躁狂症中的精神病：在严重程度和治疗反应中的作用特异性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Psychosis is a prominent characteristic of manic episodes. We investigated relationships between the presence of psychotic features, the severity of the manic syndrome, and syndrome severity's response to treatment. METHOD: 179 subjects meeting Research Diagnostic Criteria for a manic episode of bipolar I disorder were hospitalized for acute manic episodes and treated in a randomized trial of lithium, divalproex sodium, or placebo. Factor and cluster analyses were carried out using the clinician-rated Schedule for Affective Disorders and Schizophrenia, Change version (SADS-C) and the nurse-rated Affective Disorder Rating Scale (ADRS). RESULTS: Subjects with psychotic features had significantly (p <.005) greater overall impairment (lower Global Assessment Scale [GAS] scores) but did not differ in severity of mania scores compared with those without psychotic features. Psychosis factor scores correlated significantly (p <.000001) with GAS scores but not with mania scores. Baseline psychosis factor scores did not correlate with subsequent treatment-associated change in mania scores, but change in mania scores during treatment correlated significantly (p <.000001) with change in the psychosis factor. Changes in psychosis factor scores correlated significantly with changes in mania rating scale scores regardless of treatment. CONCLUSIONS: Psychotic features as a component of manic episodes contribute substantially to overall impairment. Treatments that successfully treat mania also reduce psychosis scores.
机译：背景：精神病是躁狂发作的突出特征。我们调查了精神病特征的存在，躁狂综合征的严重程度和综合征严重程度对治疗的反应之间的关系。方法：179名符合躁郁症躁狂发作研究诊断标准的受试者因急性躁狂发作住院治疗，并接受锂，双丙戊酸钠或安慰剂的随机试验治疗。使用临床医师评定的情感障碍和精神分裂症时间表，变更版本（SADS-C）和护士评定的情感障碍评定量表（ADRS）进行因子和聚类分析。结果：具有精神病特征的受试者与没有精神病特征的受试者相比，总体损伤显着（p <.005）更高（总体评估量表[GAS]得分较低），但躁狂评分的严重程度没有差异。精神病因子评分与GAS评分显着相关（p <.000001），而与躁狂评分则不相关。基线精神病因子评分与随后的与治疗相关的躁狂评分变化不相关，但治疗期间躁狂评分的变化与精神病因子变化显着相关（p <.000001）。无论治疗如何，精神病因子评分的变化与躁狂评分等级评分的变化显着相关。结论：精神病性特征是躁狂发作的重要组成部分，对总体损伤有很大影响。成功治疗躁狂症的治疗方法也会降低精神病评分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号