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首页> 外文期刊>The journal of clinical psychiatry >The use of trazodone as a hypnotic: a critical review.
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The use of trazodone as a hypnotic: a critical review.

机译：曲唑酮作为催眠药的使用：严格的审查。

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BACKGROUND: The last few years have seen a remarkable rise in the off-label use of trazodone for inducing sleep in nondepressed patients, to a degree that it is prescribed for this purpose as commonly as the leading hypnotic. In view of this widespread popularity, it seems prudent to review what is known of the safety and efficacy of trazodone when used in this context. DATA SOURCES AND SELECTION: A MEDLINE search of the literature published in English between 1975 and 2003 that included the keywords sleep, trazodone, Desyrel, depression, sleeping pill, and sedative-hypnotics was conducted. DATA SYNTHESIS: From this review, it is concluded that there are very few data to suggest that trazodone improves sleep in patients without mood disorder, though it does increase total sleep in patients with major depressive disorder. There are virtually no dose-response data for trazodone vis-a-vis sleep and, similarly, no available data on tolerance to its possible hypnotic effects. Areas of concern with its use include reports of significant dropout rates and induction of arrhythmias, primarily in patients with histories of cardiac disease, as well as the development of priapism. CONCLUSION: In summary, there are few data to support the use of trazodone in nondepressed subjects. When the risk-benefit ratio of trazodone is assessed, its side effect profile, which is much more significant than that of conventional hypnotics, should be considered.
机译：背景：最近几年，曲唑酮在非抑郁症患者中诱发睡眠的标签外使用显着增加，达到该目的通常被指定为主要催眠药。鉴于这种广泛的流行，在这种情况下使用曲唑酮的安全性和有效性的已知知识似乎是审慎的。数据来源和选择：MEDLINE对1975年至2003年期间英语出版的文献进行了MEDLINE搜索，这些文献包括关键词sleep，曲唑酮，desyrel，抑郁症，安眠药和镇静催眠药。数据综合：从本综述得出结论，很少有数据表明曲唑酮可以改善无情绪障碍患者的睡眠，尽管它确实可以增加重度抑郁症患者的总睡眠。曲唑酮对睡眠几乎没有剂量反应数据，类似地，也没有关于其可能的催眠作用耐受性的可用数据。它的使用引起关注的领域包括报告有明显的辍学率和心律不齐的诱发，主要是在有心脏病史的患者以及阴茎异常勃起的患者中。结论：总的来说，没有数据支持在非抑郁受试者中使用曲唑酮。在评估曲唑酮的风险收益比时，应考虑其副作用，该副作用比常规催眠药的副作用要重要得多。

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