• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Distinguishing roles for norepinephrine and serotonin in the behavioral effects of antidepressant drugs.
【24h】

Distinguishing roles for norepinephrine and serotonin in the behavioral effects of antidepressant drugs.

机译：去甲肾上腺素和5-羟色胺在抗抑郁药的行为作用中的重要作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antidepressant drugs have typically been classified into sets of compounds with actions targeted at serotonin (selective serotonin reuptake inhibitors [SSRIs]), norepinephrine (norepinephrine reuptake inhibitors [NRIs]), or both neurotransmitters (serotonin-norepinephrine reuptake inhibitors). Their classification has been based predominantly on their acute pharmacologic effects, usually determined by in vitro radioligand binding assays. The pharmacologic selectivity of antidepressants can be altered after their systemic administration, however, by dose, drug metabolism, physiologic interactions between neurotransmitters, and adaptive effects that emerge after chronic administration. This review examines whether pharmacologic selectivity is maintained by different types of antidepressants in vivo and whether pharmacologic selectivity matters for the production of their behavioral effects. Antidepressants increase extracellular levels of neurotransmitters according to their ability to inhibit presynaptic transporters, although physiologic interactions among neurotransmitters can influence antidepressants' selectivity in certain brain regions. Chronic administration of many antidepressants also causes down-regulation of postsynaptic and presynaptic receptors. The pattern of responses of presynaptic markers suggests that pharmacologic selectivity is maintained after chronic administration of many antidepressants. Behavioral tests indicate that depletion of serotonin (5-HT) is capable of preventing the effects produced by SSRIs but not NRIs. The depletion of catecholamines also inhibits the effects of NRIs, although test results can be complicated by inhibition of motor activity. Depletion of norepinephrine may also inhibit the effects of some SSRIs, but not highly selective SSRIs like citalopram. Although the pattern of results from in vivo tests supports the concept that parallel neurotransmitter mechanisms lead to antidepressant activity, norepinephrine may participate in the effects of some SSRIs. It is also possible that compounds with dual actions at 5-HT and norepinephrine systems may be effective under circumstances in which selective antidepressants are ineffective.
机译：抗抑郁药通常分为几类具有针对血清素（选择性5-羟色胺再摄取抑制剂[SSRIs]，去甲肾上腺素（去甲肾上腺素再摄取抑制剂[NRIs]）或两种神经递质（5-羟色胺-去甲肾上腺素再摄取抑制剂）的化合物。它们的分类主要基于其急性药理作用，通常通过体外放射配体结合测定法确定。抗抑郁药的全身给药后可以改变其药理学选择性，但是，可以通过剂量，药物代谢，神经递质之间的生理相互作用以及慢性给药后出现的适应性作用来改变。这篇综述研究了体内不同类型的抗抑郁药是否能维持药理学选择性，以及药理学选择性是否对其行为作用产生重要。抗抑郁药根据其抑制突触前转运蛋白的能力而增加神经递质的细胞外水平，尽管神经递质之间的生理相互作用会影响某些脑区域中抗抑郁药的选择性。长期服用许多抗抑郁药也会引起突触后和突触前受体的下调。突触前标记的反应模式表明，长期服用多种抗抑郁药后，药理学选择性得以保持。行为测试表明，5-羟色胺（5-HT）的消耗能够预防SSRI而非NRI产生的作用。儿茶酚胺的消​​耗也会抑制NRI的作用，尽管测试结果可能由于抑制运动活性而变得复杂。去甲肾上腺素的消耗也可能抑制某些SSRI的作用，但不能抑制西酞普兰等高选择性SSRI的作用。尽管来自体内试验的结果模式支持平行神经递质机制导致抗抑郁活性的概念，但去甲肾上腺素可能参与某些SSRI的作用。在5-HT和去甲肾上腺素系统上具有双重作用的化合物也可能在选择性抗抑郁药无效的情况下有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号