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首页> 外文期刊>The journal of clinical psychiatry >Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.
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Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.

机译：非典型抗精神病药可能引起躁狂或躁狂症：报告病例的最新综述。

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BACKGROUND: Atypical antipsychotics are widely used in clinical practice for several psychiatric disorders. Between 1994 and 1999, 26 cases of manic and hypomanic syndromes were reported with olanzapine and risperidone and were described in a previous review article. METHOD: An updated MEDLINE search (1999-2003) using the terms atypical antipsychotics, amisulpride, aripiprazole, clozapine, flupenthixol, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, zotepine, hypomania, and mania showed that 34 new cases of induced hypomanic or manic syndromes have been published, not only with olanzapine (N = 5) and risperidone (N = 6), but also with quetiapine (N = 5) and ziprasidone (N = 11) treatment. Six cases have been reported with flupenthixol and 1 with amisulpride, two antipsychotics considered as "partial" atypicals. RESULTS: A critical analysis of these case reports revealed that the effects on mood were insufficiently documented in some of the reports but that for 20 of them, evidence is highly suggestive of a causative role of atypical antipsychotics in the induction of manic/hypomanic symptomatology. CONCLUSION: This updated review continues and extends the results of the initial review and suggests that atypical antipsychotics have some intriguing effects on mood. Such effects have never been reported with conventional antipsychotics. The mechanisms involved in this phenomenon of mood switch remain to be elucidated.
机译：背景：非典型抗精神病药已广泛用于多种精神疾病的临床实践中。在1994年至1999年之间，有26例奥氮平和利培酮报告了躁狂和躁狂综合征病例，并在先前的一篇评论文章中进行了描述。方法：使用术语非典型抗精神病药，氨磺必利，阿立哌唑，氯氮平，氟喷噻醇，奥氮平，喹硫平，利培酮，司多多尔，齐拉西酮，佐特平，轻躁狂和躁狂症的术语进行的最新MEDLINE搜索（1999-2003年）显示，有34例新的轻躁狂或躁狂症病例躁狂综合征已经发表，不仅使用奥氮平（N = 5）和利培酮（N = 6），而且使用喹硫平（N = 5）和齐拉西酮（N = 11）治疗。据报道，氟喷噻索有6例，氨磺必利有1例，其中两种抗精神病药被认为是“部分”非典型药物。结果：对这些病例报告的严格分析显示，在某些报告中没有充分记录对情绪的影响，但对于其中的20例，证据高度暗示非典型抗精神病药在诱发躁狂/低躁狂症状方面具有致病作用。结论：本次更新的评论将继续并扩展最初评论的结果，并表明非典型抗精神病药对情绪有一些有趣的影响。常规抗精神病药从未报道过这种作用。这种情绪变化现象所涉及的机制仍有待阐明。

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