...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Cerebrovascular Events Among Elderly Nursing Home Patients Treated With Conventional or Atypical Antipsychotics.
【24h】

Cerebrovascular Events Among Elderly Nursing Home Patients Treated With Conventional or Atypical Antipsychotics.

机译：接受常规或非典型抗精神病药治疗的敬老院患者的脑血管事件。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Concern exists about a possible increased risk of cerebrovascular events (CVEs) among elderly patients receiving risperidone or olanzapine. We estimated the effect of atypical and conventional antipsychotics on the risk of CVEs among elderly nursing home patients with dementia. METHOD: We conducted a case-control study on residents of nursing homes in 6 U.S. states by using the Systematic Assessment of Geriatric drug use via Epidemiology database, which includes data from the Minimum Data Set linked to Medicare inpatient claims. Participants were diagnosed with Alzheimer's disease or other forms of dementia on the basis of clinical criteria and medical history (including medical records and neuroradiologic documentation). Cases included patients hospitalized for stroke or transient ischemic attack between June 30, 1998, and December 27, 1999. For each case, we identified up to 5 controls hospitalized for septicemia or urinary tract infection residing in the same facility during the same timeperiod. The sample consisted of 1130 cases and 3658 controls. RESULTS: After controlling for potential confounders, the odds ratio of being hospitalized for CVEs was 0.87 (95% CI = 0.67 to 1.12) for risperidone users, 1.32 (95% CI = 0.83 to 2.11) for olanzapine users, 1.57 (95% CI = 0.65 to 3.82) for users of other atypical agents, and 1.24 (95% CI = 0.95 to 1.63) for conventional antipsychotic users compared to nonusers of antipsychotics. A history of CVEs appeared to modify the effect of atypical antipsychotics other than risperidone on the risk of new events. CONCLUSION: Overall, no increased risk of CVEs seems to be conferred by atypical or conventional antipsychotics. Preexisting cerebrovascular risk factors might interact with some atypical antipsychotics to increase the risk of events. These results should be interpreted in light of the limitations of the study and need to be confirmed.
机译：目的：对于接受利培酮或奥氮平的老年患者，脑血管事件（CVE）的风险可能增加。我们估计了非典型和常规抗精神病药对老年痴呆症老年护理患者中CVE风险的影响。方法：我们通过流行病学数据库，通过对老年人用药的系统评估，对美国6个州的疗养院居民进行了病例对照研究，其中包括与Medicare住院索赔相关的最小数据集的数据。根据临床标准和病历（包括病历和神经放射学文献），诊断为参与者患有阿尔茨海默氏病或​​其他形式的痴呆。病例包括在1998年6月30日至1999年12月27日期间因中风或短暂性脑缺血发作住院的患者。对于每例病例，我们确定了多达5例同期在同一机构住院的败血症或泌尿道感染住院患者。样本包括1130例病例和3658例对照。结果：在控制了潜在的混杂因素后，利培酮使用CVE住院的几率是0.87（95％CI = 0.67至1.12），奥氮平使用者是1.32（95％CI = 0.83至2.11），1.57（95％CI）与非抗精神病药物的非使用者相比，其他非典型药物的使用者= 0.65至3.82），传统抗精神病药物的使用者为1.24（95％CI = 0.95至1.63）。 CVE的历史似乎改变了利培酮以外的非典型抗精神病药对新事件风险的影响。结论：总体而言，非典型或常规抗精神病药似乎不会增加CVE的风险。先前存在的脑血管危险因素可能会与一些非典型抗精神病药物相互作用，从而增加发生事件的风险。应根据研究的局限性来解释这些结果，并需要加以证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号