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首页> 外文期刊>The journal of clinical psychiatry >Olanzapine Versus Risperidone in Newly Admitted Acutely Ill Psychotic Patients.
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Olanzapine Versus Risperidone in Newly Admitted Acutely Ill Psychotic Patients.

机译：新入院的急性精神病患者的奥氮平与利培酮比较。

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OBJECTIVE: Risperidone and olanzapine are the 2 most widely prescribed second-generation anti-psychotics. The purpose of this study was to compare the efficacy of risperidone and olanzapine using duration of hospitalization as the primary outcome measure. This outcome was selected as it is an indirect measure of how well patients are responding to the medication and represents a "real world" endpoint relevant to practicing hospital psychiatrists. METHOD: The study was done at a large state psychiatric hospital in North Carolina from 2001 to 2003. Subjects were eligible for inclusion if they required treatment with an antipsychotic (e.g., positive symptoms) and were able to provide informed consent. Eighty-five patients entered the study and were randomly assigned to risperidone (N = 40) or olanzapine (N = 45) as their initial antipsychotic. Treatment was naturalistic, and dosing was based on the discretion of the treating physician. RESULTS: There was no significant difference in the mean durations of hospitalization for the risperidone group (7.9 days) as compared to the olanzapine group (8.1 days). There were no significant differences in the demographics of either treatment group, but, during the study, risperidone-treated patients used more antihistamines (chi(2) = 4.0, p = .05). Eighty percent of each group (N = 36, olanzapine; N = 32, risperidone) remained on the study medication at discharge. CONCLUSIONS: Risperidone and olanzapine were equally efficacious, suggesting that measures other than "efficacy" (e.g., side effects, cost) should be considered when determining overall effectiveness
机译：目的：利培酮和奥氮平是两种处方最广泛的第二代抗精神病药。这项研究的目的是比较住院期间为主要结果指标的利培酮和奥氮平的疗效。选择该结果是因为它是患者对药物反应的良好程度的间接度量，并且代表了与医院精神科医生相关的“现实世界”终点。方法：这项研究于2001年至2003年在北卡罗来纳州的一家大型州立精神病医院进行。如果受试者需要接受抗精神病药（例如阳性症状）的治疗并且能够提供知情同意，则有资格纳入研究。八十五名患者进入研究，被随机分配为利培酮（N = 40）或奥氮平（N = 45）作为他们最初的抗精神病药。治疗是自然的，并且剂量是根据治疗医师的判断来确定的。结果：与奥氮平组（8.1天）相比，利培酮组（7.9天）的平均住院时间没有显着差异。两个治疗组的人口统计学差异均无统计学意义，但在研究期间，利培酮治疗的患者使用了更多的抗组胺药（chi（2）= 4.0，p = .05）。每组百分之八十（N = 36，奥氮平; N = 32，利培酮）出院时仍在研究药物上。结论：利培酮和奥氮平的疗效相同，表明在确定总体疗效时应考虑除“疗效”以外的其他措施（例如副作用，成本）

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