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Female reproductive cycle and obsessive-compulsive disorder.

机译:女性生殖周期和强迫症。

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BACKGROUND: The aim of our study was to assess whether there is a relationship between reproductive cycle events and the initiation or changes in symptoms of obsessive-compulsive disorder (OCD). METHOD: Forty-six female outpatients meeting DSM-IV criteria for OCD completed a semistructured interview at our OCD unit to assess the relationship between reproductive cycle events and OCD. Dates of data collection were from January 2001 to December 2003. RESULTS: In our sample, OCD onset occurred in the same year as menarche in 22% (N = 10), at pregnancy in 2% (N = 1), at postpartum in 7% (N = 3), and at menopause in 2% (N = 1). Worsening of preexisting OCD was reported by 20% of patients (9/45) at premenstruum, 8% (1/12) at pregnancy, 50% (6/12) at postpartum, and 8% (1/12) at menopause. The number of premenstrual mood symptoms, which included anxiety, irritability, mood lability and depressed mood, was associated with both premenstrual worsening of OCD (OR = 5.1, p < .01) and onset or worsening of OCD at postpartum (OR = 2.7, p < .05). Patients with an onset or worsening of OCD at postpartum also more frequently reported pre-menstrual worsening of OCD and previous history of major depressive disorder, including postpartum depression (p
机译:背景:我们的研究目的是评估生殖周期事件与强迫症(OCD)症状的发生或变化之间是否存在关系。方法:46名符合DSM-IV强迫症标准的女性门诊患者在我们的强迫症部门完成了半结构化访谈,以评估生殖周期事件与强迫症之间的关系。数据收集日期为2001年1月至2003年12月。结果:在我们的样本中,OCD的发生与初潮在同一年发生,为22%(N = 10),怀孕时为2%(N = 1),在产后。 7%(N = 3),更年期为2%(N = 1)。据报道,月经前20%(9/45),妊娠时8%(1/12),产后50%(6/12)和绝经后8%(1/12)的患者已有的OCD恶化。经前情绪症状的数量,包括焦虑,烦躁,情绪不稳和情绪低落,与经前强迫症恶化(OR = 5.1,p <.01)以及产后强迫症发作或恶化(OR = 2.7, p <.05)。产后强迫症发作或恶化的患者也更频繁地报告月经前强迫症恶化和以前的主要抑郁症病史,包括产后抑郁症(全部p≤0.05)。结论:在许多患者中,强迫症的发作或恶化与生殖周期事件有关,尤其是在初潮和产后。某些患有强迫症的妇女似乎在不同的生殖时期容易受到强迫症恶化的影响,这暗示着荷尔蒙的波动,而经前和产后是这两个具有更大脆弱性的生殖事件。那些强迫症症状似乎与生殖事件有关的患者也表现出更大的情绪症状史(经前抑郁和严重抑郁发作)。

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