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首页> 外文期刊>The journal of clinical psychiatry >Receptor-binding profiles of antipsychotics: clinical strategies when switching between agents.
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Receptor-binding profiles of antipsychotics: clinical strategies when switching between agents.

机译：抗精神病药的受体结合概况：在药物之间进行切换时的临床策略。

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In spite of apparent improvements in the pharmacotherapy of schizophrenia, many patients still demonstrate an incomplete therapeutic response to antipsychotic medication and/or intolerable adverse effects, necessitating a change in their medication regimen. The switch from one antipsychotic to another, however, is not without challenges and can be complicated by withdrawal-emergent adverse effects that prompt the patient or the clinician to abort the switch. The extent to which these adverse events can be predicted by comparing the effects of the old and new antipsychotic medications on various receptor systems, including dopaminergic, muscarinic, and histaminergic receptors, is of considerable clinical and research interest. For example, patients receiving a sedating antipsychotic with high affinity for histamine H(1) receptors could experience rebound insomnia if switched to a less sedating agent with a low affinity for H(1) receptors. An understanding of the differential receptor-binding profiles ofthe various antipsychotics can help clinicians anticipate and manage potential clinical issues that may be encountered when switching antipsychotic therapy.
机译：尽管精神分裂症的药物治疗有明显改善，但许多患者仍然表现出对抗精神病药物的治疗反应不完全和/或无法忍受的不良反应，因此有必要改变药物治疗方案。但是，从一种抗精神病药向另一种抗精神病药的转换并非没有挑战，并且会因撤药而引起的副作用（使患者或临床医生中止转换）而变得复杂。通过比较新旧抗精神病药对各种受体系统（包括多巴胺能，毒蕈碱和组胺能受体）的作用，可以预测这些不良事件的程度，在临床和研究中都具有重要意义。例如，如果患者接受对组胺H（1）受体具有高亲和力的镇静抗精神病药，如果改用对H（1）受体具有低亲和力的镇静剂，则可能会出现反弹性失眠。了解各种抗精神病药物的差异性受体结合谱可以帮助临床医生预测和管理在切换抗精神病药物治疗时可能遇到的潜在临床问题。

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