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首页> 外文期刊>The journal of clinical psychiatry >Acupuncture for the treatment of major depressive disorder: a randomized controlled trial.
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Acupuncture for the treatment of major depressive disorder: a randomized controlled trial.

机译：针灸治疗重度抑郁症：一项随机对照试验。

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BACKGROUND: Over 50% of patients with major depressive disorder (MDD) either do not tolerate or do not respond to antidepressant medications. Several preliminary studies have shown the benefits of acupuncture in the treatment of depression. We sought to determine whether a 2-point electroacupuncture protocol (verum acupuncture) would be beneficial for MDD, in comparison to needling at nonchannel scalp points with sham electrostimulation (control acupuncture). METHOD: Fifty-three subjects aged 18-80 years, recruited via advertisement or referral, were included in the primary analysis of our randomized controlled trial, which was conducted from March 2004 through May 2007 at UPMC Shadyside, Center for Complementary Medicine, in Pittsburgh, Pennsylvania. Inclusion criteria were mild or moderate MDD (according to the Structured Clinical Interview for DSM-IV Axis I Disorders) and a score of 14 or higher on the Hamilton Depression Rating Scale (HDRS). Exclusion criteria included severe MDD, seizure disorder or risk for seizure disorder, psychosis, bipolar disorder, chronic MDD, treatment-resistent MDD, and history of substance abuse in the prior 6 months. Patients were randomized to receive twelve 30-minute sessions of verum versus control acupuncture over 6 to 8 weeks. The HDRS was the primary outcome measure. The UKU Side Effect Rating Scale was used to assess for adverse effects. RESULTS: Twenty-eight subjects were randomized to verum electroacupuncture and 25 to control acupuncture. The 2 groups did not differ with regard to gender, age, or baseline severity of depression. Both groups improved, with mean (SD) absolute HDRS score decreases of -6.6 (5.9) in the verum group and -7.6 (6.6) in the control group, corresponding to 37.5% and 41.3% relative decreases from baseline. There were no serious adverse events associated with either intervention, and endorsement of adverse effects was similar in the 2 groups. CONCLUSIONS: We were unable to demonstrate a specific effect of electroacupuncture. Electroacupuncture and control acupuncture were equally well tolerated, and both resulted in similar absolute and relative improvement in depressive symptoms as measured by the HDRS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00071110.
机译：背景：超过50％的重度抑郁症（MDD）患者不耐受或对抗抑郁药无反应。几项初步研究表明，针灸可治疗抑郁症。我们试图确定与假手术电刺激（对照针灸）在非通道头皮点进行针刺相比，两点电针灸方案（普通针灸）是否对MDD有益。方法：2004年3月至2007年5月在美国匹兹堡补充医学中心UPMC Shadyside进行的随机对照试验的初步分析中，纳入了通过广告或推荐方式招募的53名年龄在18-80岁之间的受试者。 ，宾夕法尼亚州。纳入标准为轻度或中度MDD（根据针对DSM-IV轴I障碍的结构性临床访谈），汉密尔顿抑郁量表（HDRS）得分为14分或更高。排除标准包括严重的MDD，癫痫发作或癫痫发作的风险，精神病，躁郁症，慢性MDD，抗药性MDD以及前6个月的药物滥用史。在6至8周内，将患者随机接受十二次30分钟的Verum对比对照针灸治疗。 HDRS是主要的结局指标。 UKU副作用评定量表用于评估不良反应。结果：28名受试者被随机分为普通电针疗法和25名对照针刺疗法。两组在性别，年龄或抑郁的基线严重程度方面无差异。两组均得到改善，verum组的平均（SD）绝对HDRS得分降低了-6.6（5.9），而对照组的平均（SD）降低了-7.6（6.6），相对于基线相对降低了37.5％和41.3％。两种干预措施均无严重不良事件发生，并且对不良反应的认可在两组中相似。结论：我们无法证明电针的特定效果。通过HDRS测量，电针和对照针灸的耐受性均相同，并且两者均导致抑郁症状的相似绝对和相对改善。试验注册：clinicaltrials.gov标识符：NCT00071110。

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