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首页> 外文期刊>The journal of clinical psychiatry >D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: A meta-analysis
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D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: A meta-analysis

机译：D-环丝氨酸增强行为疗法治疗焦虑症的荟萃分析

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Objective: To determine the efficacy of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Data Sources and Study Selection: Using the search terms D-cycloserine AND anxiety disorders (MeSH), PubMed (1965-June 2011), PsycINFO, and Scopus were searched for randomized, double-blind, placebo-controlled trials of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Anxiety disorders were defined as any disorder categorized as such in DSM-IV-TR. Data Extraction: A random-effects model was used to calculate the standardized mean difference of change in anxiety rating scale scores with D-cycloserine augmentation compared to placebo, which was the primary outcome measure. Subgroup analysis and meta-regression were used to examine the effects of D-cycloserine dosage and timing (relative to exposure therapy), diagnostic indication, number of therapy sessions, and trial methodological quality on D-cycloserine efficacy. Results: Meta-analysis of 9 trials involving 273 subjects demonstrated a significant benefit from D-cycloserine augmentation (standardized mean difference = 0.46 [95% CI, 0.15 to 0.77], z = 2.89, P = .004). There was no evidence of publication bias, but a moderate, nonsignificant degree of heterogeneity between trials (I 2 = 36%, Q = 12.6, df = 8, P = .12) was found. Secondary analyses yielded no significant findings. Conclusions: D-Cycloserine appears to be an effective augmentation agent that enhances the effects of behavioral therapy in the treatment of anxiety disorders. In contrast to a previous meta-analysis that examined D-cycloserine's effects in both animals and humans, we found no evidence of an effect of dose number, dose timing, or dosage of D-cycloserine on reported efficacy in the ranges studied.
机译：目的：确定行为疗法的D-环丝氨酸增强治疗焦虑症的疗效。数据来源和研究选择：使用搜索词D-环丝氨酸和焦虑症（MeSH），PubMed（1965年6月至2011年6月），PsycINFO和Scopus进行D-环丝氨酸增强的随机，双盲，安慰剂对照试验行为疗法治疗焦虑症。焦虑症定义为在DSM-IV-TR中归类为此类的任何疾病。数据提取：与安慰剂相比，采用随机效应模型计算D-环丝氨酸增强焦虑评估量表评分变化的标准化均值差，安慰剂是主要的结局指标。亚组分析和Meta回归用于检查D-环丝氨酸剂量和时机（相对于暴露疗法），诊断适应症，治疗疗程数和试验方法学质量对D-环丝氨酸功效的影响。结果：对涉及273名受试者的9项试验的荟萃分析表明，D-环丝氨酸增强治疗具有显着益处（标准化平均差= 0.46 [95％CI，0.15至0.77]，z = 2.89，P = .004）。没有证据表明发表有偏倚，但是发现试验之间存在中等程度的，非显着性的异质性（I 2 = 36％，Q = 12.6，df = 8，P = 0.12）。二级分析未发现重大发现。结论：D-环丝氨酸似乎是一种有效的增强剂，可增强行为疗法在治疗焦虑症中的作用。与先前的荟萃分析检查了D-环丝氨酸在动物和人类中的作用相反，我们没有发现在研究的范围内剂量，剂量时机或剂量对D-环丝氨酸的报道功效有影响的证据。

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