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首页> 外文期刊>The journal of clinical psychiatry >Potentially significant versus clinically significant drug interactions: Pomegranate juice as a case in point
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Potentially significant versus clinically significant drug interactions: Pomegranate juice as a case in point

机译：潜在的显着性与临床上显着的药物相互作用：以石榴汁为例

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摘要

In vitro and in vivo laboratory data show that pomegranate juice consistently inhibits intestinal CYP2C9 and CYP3A4 enzymes. Pomegranate juice may therefore increase the bioavailability of drugs that are metabolized by these enzymes. However, studies in humans find that pomegranate juice does not increase exposure to either CYP2C9 or CYP3A4 substrates. These contradictory findings suggest that potential drug interactions identified in the laboratory may not necessarily translate into clinically significant drug interactions in humans, and hence that laboratory data are insufficient grounds upon which clinical decisions may be based.
机译：体外和体内实验室数据显示，石榴汁始终抑制肠道CYP2C9和CYP3A4酶。因此，石榴汁可以增加被这些酶代谢的药物的生物利用度。但是，人体研究发现石榴汁不会增加对CYP2C9或CYP3A4底物的暴露。这些矛盾的发现表明，实验室中鉴定出的潜在药物相互作用可能不一定会转化为人类临床上重要的药物相互作用，因此实验室数据不足以作为临床决策的依据。

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