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首页> 外文期刊>The journal of clinical psychiatry >Assessing Cognitive Function in Bipolar Disorder: Challenges and Recommendations for Clinical Trial Design
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Assessing Cognitive Function in Bipolar Disorder: Challenges and Recommendations for Clinical Trial Design

机译：评估双相情感障碍的认知功能：临床试验设计的挑战和建议

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Objective: Neurocognitive impairment in schizophrenia has been recognized for more than a century. In contrast, only recently have significant neurocognitive deficits been recognized in bipolar disorder. Converging data suggest the importance of cognitive problems in relation to quality of life in bipolar disorder, highlighting the need for treatment and prevention efforts targeting cognition in bipolar patients. Future treatment trials targeting cognitive deficits will be met with methodological challenges due to the inherent complexity and heterogeneity of the disorder, including significant diagnostic comorbidities, the episodic nature of the illness, frequent use of polypharmacy, cognitive heterogeneity, and a lack of consensus regarding measurement of cognition and outcome in bipolar patients. Guidelines for use in designing future trials are needed.
机译：目的：精神分裂症的神经认知损害​​已被认识超过一个世纪。相反，双相情感障碍仅在最近才认识到明显的神经认知缺陷。越来越多的数据表明，与双相情感障碍患者的生活质量相关的认知问题非常重要，这凸显了针对双相情感障碍患者的针对认知的治疗和预防工作的必要性。由于该疾病固有的复杂性和异质性，未来针对认知缺陷的治疗试验将面临方法上的挑战，包括重大的诊断合并症，疾病的发作性，多药房的频繁使用，认知异质性以及对测量缺乏共识躁郁症患者的认知和预后。需要用于设计未来试验的指南。

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