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首页> 外文期刊>The journal of clinical psychiatry >Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study.
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Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study.

机译：患有失眠症的医学疾病患者的褪黑激素：一项双盲，安慰剂对照研究。

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BACKGROUND: It has been suggested that melatonin improves sleep functioning, but this possibility has not been studied in medical populations. METHOD: 33 medically ill persons with initial insomnia were randomly assigned to receive either melatonin (N = 18) or placebo (N = 15) in a flexible-dose regimen. Double-blind assessments of aspects of sleep functioning were obtained daily across the next 8 to 16 days. RESULTS: The mean stable dose of melatonin was found to be 5.4 mg. Relative to placebo, melatonin significantly hastened sleep onset, improved quality and depth of sleep, and increased sleep duration without producing drowsiness, early-morning "hangover" symptoms, or daytime adverse effects (p < .05). Melatonin also contributed to freshness in the morning and during the day and improved overall daytime functioning. Benefits were most apparent during the first week of treatment. CONCLUSION: Melatonin may be a useful hypnotic for medically ill patients with initial insomnia, particularly those for whom conventional hypnotic drug therapy may be problematic.
机译：背景：有人提出褪黑激素可改善睡眠功能，但尚未在医学人群中研究这种可能性。方法：将33名最初失眠的内科疾病患者随机分配为以灵活剂量方案接受褪黑激素（N = 18）或安慰剂（N = 15）。在接下来的8到16天中，每天都会获得有关睡眠功能方面的双盲评估。结果：褪黑激素的平均稳定剂量为5.4 mg。相对于安慰剂，褪黑激素可显着加速睡眠发作，改善睡眠质量和深度，并增加睡眠时间，而不会产生嗜睡，早间“宿醉”症状或白天的不良反应（p <.05）。褪黑激素还有助于早晨和白天的新鲜感，并改善白天的整体功能。在治疗的第一周，益处最为明显。结论：褪黑激素可能是一种有益的催眠药，适用于初次失眠的医疗疾病患者，尤其是对于那些常规催眠药物治疗可能有问题的患者。

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