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首页> 外文期刊>The journal of clinical psychiatry >Suicidality and substance abuse in affective disorders.
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Suicidality and substance abuse in affective disorders.

机译：情感障碍中的自杀和药物滥用。

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摘要

The relationship between suicidality and substance abuse has long been recognized, although studies have only fairly recently begun to identify factors that may help clarify how alcohol or other drug abuse increases the susceptibility to suicidal behavior in vulnerable populations. In particular, alcohol and other psychoactive substance misuse has been linked with mood destabilization and the induction of manic or depressive episodes in affectively ill individuals, while also demarcating groups with heightened tendencies toward impulsivity, aggression, and sensitivity to interpersonal loss. Serotonergic mechanisms have been implicated in each of these clinical settings, along with possible dysregulation of other neurotransmitter systems. Psychosocial aspects of alcohol or drug abuse relevant to suicide may involve a heightened sensitivity to interpersonal loss, poor coping skills in response to adverse life events, and affective dysregulation induced by circadian and psychosocial stresses. Consequently, self-destructive behaviors with relatively little premeditation may arise during periods of increased stress, intoxication, depression, or other psychopathology. Early detection of substance abuse followed by appropriate pharmacologic and/or psychotherapeutic interventions may greatly help to minimize the formation of complex comorbid psychiatric conditions and reduce the potential for suicidal acts among high-risk populations.
机译：自杀与药物滥用之间的关系早已得到认可，尽管研究只是在最近才开始确定可能有助于阐明饮酒或其他药物滥用如何增加脆弱人群自杀行为敏感性的因素。特别是，酗酒和其他精神活性物质滥用与情绪不稳定的人的情绪不稳定和诱发躁狂或抑郁发作有关，同时也区分了易冲动，攻击性和对人际交往敏感度较高的人群。在所有这些临床情况中，都涉及了血清素能机制，以及其他神经递质系统的可能失调。与自杀有关的酗酒或吸毒的社会心理方面可能涉及对人际交往的敏感性提高，对不良生活事件的应对能力差以及由昼夜节律和社会心理压力引起的情感失调。因此，在压力增加，陶醉，抑郁或其他心理病理期间，可能会发生预想较少的自我毁灭行为。尽早发现药物滥用，然后采取适当的药物和/或心理治疗干预措施，可能会极大地有助于最大程度地减少复杂的合并精神病状况的形成，并降低高危人群自杀行为的可能性。

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