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首页> 外文期刊>The journal of clinical psychiatry >Pregnancy Outcome of Women Using Atypical Antipsychotic Drugs: A Prospective Comparative Study.
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Pregnancy Outcome of Women Using Atypical Antipsychotic Drugs: A Prospective Comparative Study.

机译：使用非典型抗精神病药的妇女的妊娠结局：一项前瞻性比较研究。

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BACKGROUND: A substantial number of women of childbearing age suffer from schizophrenia and other mental illnesses that require the use of antipsychotic drugs. Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy. OBJECTIVES: (1) To determine whether atypical antipsychotics increase the rate of major malformations above the 1% to 3% baseline risk seen in the general population. (2) To examine rates of spontaneous and therapeutic abortions, rates of stillbirths, birth weight, and gestational age at birth. METHOD: The cohort was composed of pregnant women who contacted the Motherisk Program in Canada or the Israeli Teratogen Information Service in Israel and women who were recruited from the Drug Safety Research Unit database in England. Women who had been exposed to atypical antipsychotics were matched to a comparison group of pregnant women who had not been exposed to these agents. RESULTS: Data wereobtained on 151 pregnancy outcomes that included exposure to olanzapine (N= 60), risperidone (N = 49), quetiapine (N = 36), and clozapine (N = 6). Among women exposed to an atypical antipsychotic, there were 110 live births (72.8%), 22 spontaneous abortions (14.5%), 15 therapeutic abortions (9.9%), and 4 stillbirths (2.6%). Among babies of women in this group, there was 1 major malformation (0.9%), and the mean +/-SD birth weight was 3341 +/-685 g. There were no statistically significant differences in any of the pregnancy outcomes of interest between the exposed and comparison groups, with the exceptions of the rate of low birth weight, which was 10% in exposed babies compared with 2% in the comparison group (p = .05), and the rate of therapeutic abortions (p = .003). CONCLUSION: These results suggest that atypical antipsychotics do not appear to be associated with an increased risk for major malformations.
机译：背景：许多育龄妇女患有精神分裂症和其他需要使用抗精神病药物的精神疾病。自1990年代中期以来，非典型抗精神病药已投放市场，迄今为止，尚无关于妊娠期使用的前瞻性比较研究。目的：（1）确定非典型抗精神病药是否能使一般人群中主要畸形的发生率超过基线风险的1％至3％。 （2）检查自然流产和治疗流产的比率，死产的比率，出生体重和出生时的胎龄。方法：该队列由与加拿大的Motherisk计划或以色列的以色列致畸信息服务局联系的孕妇和从英格兰药物安全研究室数据库招募的妇女组成。暴露于非典型抗精神病药的妇女与未暴露于这些药物的孕妇进行比较。结果：获得了151例妊娠结局的数据，包括奥氮平（N = 60），利培酮（N = 49），喹硫平（N = 36）和氯氮平（N = 6）。在接受非典型抗精神病药治疗的妇女中，有110例活产（72.8％），22例自然流产（14.5％），15例治疗性流产（9.9％）和4例死胎（2.6％）。在该组妇女的婴儿中，有1个主要畸形（0.9％），平均+/- SD出生体重为3341 +/- 685 g。暴露组和比较组之间，任何感兴趣的妊娠结局均无统计学上的显着差异，但低出生体重的比率为10％，而对照组为2％（p = .05），以及治疗性流产的比率（p = .003）。结论：这些结果表明非典型抗精神病药似乎与重大畸形风险增加无关。

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