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首页> 外文期刊>The journal of clinical psychiatry >Patient compliance to a new enteric-coated weekly formulation of fluoxetine during continuation treatment of major depressive disorder.
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Patient compliance to a new enteric-coated weekly formulation of fluoxetine during continuation treatment of major depressive disorder.

机译：在持续治疗重度抑郁症期间，患者应遵从氟西汀每周一次的新肠溶衣配方。

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BACKGROUND: A new formulation of enteric-coated fluoxetine given once weekly could be a useful option for the long-term treatment of depression, but compliance to once-weekly fluoxetine treatment has not been assessed. METHOD: Patients were adults from the United Kingdom who had responded to fluoxetine treatment for a current episode of depression (DSM-IV criteria). In the baseline assessment phase, all patients (N = 117) were continued on 20 mg of open-label fluoxetine once daily for 4 weeks. In the follow-up phase, patients (N = 109) were randomly assigned to once-weekly or once-daily fluoxetine for 3 months. Patient compliance was monitored by electronic devices during both phases of the study. RESULTS: Compliance to once-weekly fluoxetine treatment was higher than compliance to once-daily fluoxetine (85.9% vs. 79.4%, respectively). CONCLUSION: Once-weekly fluoxetine treatment allows for new flexibility for both the clinician and the patient, and this study alleviates the concern that patients will forget weekly doses.
机译：背景：每周一次给予肠溶性氟西汀的新制剂可能是长期治疗抑郁症的有用选择，但尚未评估每周氟西汀治疗的依从性。方法：患者是来自英国的成年人，他们对氟西汀治疗导致当前的抑郁发作（DSM-IV标准）有反应。在基线评估阶段，所有患者（N = 117）每天持续服用20 mg开放标签氟西汀，持续4周。在随访阶段，将患者（N = 109）随机分配到每周一次或每天一次氟西汀治疗3个月。在研究的两个阶段均通过电子设备监测患者的依从性。结果：每周一次氟西汀治疗的依从性高于每天一次氟西汀的依从性（分别为85.9％和79.4％）。结论：每周一次的氟西汀治疗为临床医生和患者提供了新的灵活性，这项研究缓解了患者忘记每周剂量的担忧。

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