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首页> 外文期刊>The journal of clinical psychiatry >Medication continuation and compliance: a comparison of patients treated with clozapine and haloperidol.
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Medication continuation and compliance: a comparison of patients treated with clozapine and haloperidol.

机译：药物持续性和依从性：比较氯氮平和氟哌啶醇的患者。

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BACKGROUND: This study compares medication continuation and regimen compliance with the atypical antipsychotic medication clozapine versus the conventional antipsychotic haloperidol. METHOD: Data from a 15-site double-blind, randomized clinical trial (N = 423) were used to compare patients with DSM-III-R schizophrenia assigned to clozapine or haloperidol in terms of duration of participation while taking the randomly assigned study drug (continuation) and the proportion of prescribed pills that were taken (compliance). Multiple regression analysis was used to determine the relationship of baseline characteristics and measures of clinical change to continuation for the entire sample and for patients assigned to each medication. RESULTS: Patients assigned to clozapine continued taking the study drug for a mean of 35.5 weeks as compared with only 27.2 among patients assigned to haloperidol (F = 4.45, df = 1,422; p = .0001). No differences were found between the groups in the proportion of prescribed pills that were returned at any timepoint. Among patients assigned to haloperidol, poorer continuation was associated with being older and greater continuation with receiving public support. Among patients on clozapine treatment, continuation was poorer among African American patients and greater among patients who showed reduced clinical symptoms and akathisia. Continuation with clozapine was greater even after adjusting for these factors. CONCLUSION: Continuation with medication is greater with clozapine than haloperidol and is partly explained by greater symptom improvement and reduced side effects. No differences were found in regimen compliance.
机译：背景：本研究比较了非典型抗精神病药物氯氮平与常规抗精神病药物氟哌啶醇的药物持续性和方案依从性。方法：采用15个站点的双盲，随机临床试验（N = 423）中的数据，比较服用随机分配的研究药物时，服用氯氮平或氟哌啶醇的DSM-III-R精神分裂症患者的持续时间（续）和服用的处方药比例（依从性）。多元回归分析用于确定整个样本以及分配给每种药物的患者的基线特征和临床变化与持续性之间的关系。结果：分配给氯氮平的患者继续服用该研究药物的平均时间为35.5周，而分配给氟哌啶醇的患者中该比例仅为27.2（F = 4.45，df = 1,422; p = .0001）。两组之间在任何时间点返回的处方药的比例均无差异。在分配给氟哌啶醇的患者中，较差的持续性与年龄较大有关，而在获得公众支持的情况下具有较大的持续性。在接受氯氮平治疗的患者中，非裔美国人患者的延续性较差，而临床症状和静坐症减轻的患者中延续性较高。调整了这些因素后，氯氮平的持续用药率更高。结论：氯氮平比氟哌啶醇的用药持续时间更大，部分原因是症状改善和副作用减少。在方案依从性方面未发现差异。

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