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首页> 外文期刊>The journal of clinical psychiatry >A Placebo-Controlled, Randomized, Double-Blind Study of Adjunctive Bupropion Sustained Release in the Treatment of SSRI-Induced Sexual Dysfunction.
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A Placebo-Controlled, Randomized, Double-Blind Study of Adjunctive Bupropion Sustained Release in the Treatment of SSRI-Induced Sexual Dysfunction.

机译：安慰剂对照，随机双盲研究辅助性安非他酮缓释治疗SSRI引起的性功能障碍。

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BACKGROUND: Sexual side effects are among the common reasons patients discontinue selective serotonin reuptake inhibitors (SSRIs). While many antidotes have been proposed, few have been subjected to double-blind trials. Some evidence has suggested that bupropion may be an effective antidote for SSRI-induced sexual dysfunction. In this double-blind trial, the efficacy of a standard dose of bupropion sustained release (SR) is evaluated in the treatment of SSRI-induced sexual dysfunction. METHOD: Patients with a history of SSRI-induced sexual side effects were randomly assigned to adjunctive treatment with either bupropion SR 150 mg daily or placebo for 6 weeks. Assessments of sexual function and interest included the Arizona Sexual Experiences Scale (ASEX), Brief Index of Sexual Functioning, and a 10-point visual analogue scale. Efficacy was defined as a 50% improvement on the ASEX at the end of 6 weeks. Data were collected from January 1999 to March 2001. RESULTS: Forty-one patients entered the study and completed the 6-week trial. No significant differences were seen between placebo and bupropion SR on the ASEX or on any measure of sexual functioning at the end of the trial. CONCLUSION: A fixed dose of 150 mg/day of bupropion SR taken in the morning does not appear to be effective in the treatment of SSRI-induced sexual dysfunction. Additional trials will be required to define what role, if any, bupropion might have in the treatment of SSRI-induced sexual side effects.
机译：背景：性副作用是患者停用选择性血清素再摄取抑制剂（SSRI）的常见原因之一。尽管已经提出了许多解毒剂，但很少有人进行过双盲试验。一些证据表明，安非他酮可能是SSRI引起的性功能障碍的有效解毒剂。在该双盲试验中，对标准剂量安非他酮缓释（SR）的疗效进行了SSRI诱导的性功能障碍的治疗。方法：将有SSRI诱发性副作用史的患者随机分配为辅助治疗，每天150 mg安非他酮或安慰剂6周。对性功能和兴趣的评估包括亚利桑那州性经验量表（ASEX），性功能简要指数和10分视觉类比量表。功效定义为在6周结束时ASEX改善50％。从1999年1月至2001年3月收集了数据。结果：41名患者进入研究并完成了为期6周的试验。在试验结束时，在ASEX或任何性功能测量方法上，安慰剂和安非他酮SR之间没有发现显着差异。结论：早晨服用固定剂量的安非他酮SR每天150 mg，似乎不能有效治疗SSRI引起的性功能障碍。需要进一步的试验来确定安非他酮在治疗SSRI引起的性副作用中可能起什么作用。

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