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首页> 外文期刊>The journal of clinical psychiatry >Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression.
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Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression.

机译：电抽搐治疗可增加脑源性神经营养因子的血浆浓度：对重度抑郁症患者的一项初步研究。

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OBJECTIVE: The therapeutic mechanism of electroconvulsive therapy (ECT) is unknown. Animal research supports a neurotrophic effect of ECT. To investigate a neurotrophic effect in humans, we examined whether plasma concentration of brain-derived neurotrophic factor (BDNF) increases in patients receiving ECT for major depression. METHOD: We conducted a prospective, self-controlled study of 15 patients with a DSM-IV diagnosis of major depressive episode who were referred for ECT at the University of Maryland Medical Center (Baltimore, Md.) between January 2004 and September 2005. Plasma BDNF concentration was measured by enzyme-linked immunosorbent assay before and during an acute course of ECT. Depression severity was measured using the 21-item Hamilton Rating Scale for Depression (HAM-D). RESULTS: ECT resulted in a significant increase in plasma BDNF (Z = 2.897, p = .004) from a pre-ECT median of 84.9 pg/mL to a post-ECT median of 141.2 pg/mL. This change was accompanied by a significant decrease in HAM-D score (Z = 3.411, p = .001) from a pre-ECT median of 30.0 to a post-ECT median of 9.0. BDNF increased in 13 (86.7%) of 15 subjects. CONCLUSION: This is the first report of an increase in plasma BDNF concentration in patients receiving ECT. These preliminary results encourage further investigation of a neurotrophic mechanism for the antidepressant effect of ECT.
机译：目的：电痉挛疗法（ECT）的治疗机制尚不清楚。动物研究支持ECT的神经营养作用。为了研究对人类的神经营养作用，我们检查了接受ECT治疗的严重抑郁症患者的脑源性神经营养因子（BDNF）血浆浓度是否增加。方法：我们对2004年1月至2005年9月在马里兰大学医学中心（马里兰州巴尔的摩）转诊接受ECT的15例DSM-IV诊断为重度抑郁发作的患者进行了一项前瞻性，自我对照研究。在ECT的急性过程之前和期间，通过酶联免疫吸附测定法测量BDNF浓度。使用21个项的汉密尔顿抑郁量表（HAM-D）测量抑郁的严重程度。结果：ECT导致血浆BDNF显着增加（Z = 2.897，p = .004），从ECT前的中位数84.9 pg / mL到ECT后的中位数141.2 pg / mL。这种变化伴随着HAM-D分数的显着降低（Z = 3.411，p = .001），从ECT前的中位数30.0降至ECT后的中位数9.0。 15名受试者中有13名（86.7％）的BDNF升高。结论：这是接受ECT治疗的患者血浆BDNF浓度升高的首次报道。这些初步结果鼓励进一步研究ECT的抗抑郁作用的神经营养机制。

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