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首页> 外文期刊>The journal of clinical psychiatry >Association of subjective well-being, symptoms, and side effects with compliance after 12 months of treatment in schizophrenia.
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Association of subjective well-being, symptoms, and side effects with compliance after 12 months of treatment in schizophrenia.

机译：精神分裂症治疗12个月后主观幸福感，症状和副作用与依从性的关系。

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OBJECTIVE: Subjective well-being is considered important for compliance with antipsychotic treatment. The objective of this post hoc analysis of data from German patients in the Schizophrenia Outpatient Health Outcomes study was to investigate subjective well-being and compliance, with consideration of clinical symptoms and side effects, in outpatients diagnosed with schizophrenia. METHOD: In a multicenter observational study of 2960 patients with DSM-IV-defined schizophrenia recruited between January and December 2001, subjective well-being was measured during 12 months with the Subjective Well-Being Under Neuroleptic Treatment Scale, short version (SWN-K). Compliance was self- and physician-rated. The association of compliance with clinical parameters was assessed by logistic regression. RESULTS: Factor analysis resulted in 3 factors: SWN-K (r2 = 0.867), clinical symptoms (r2 = 0.744), and side effects (r2 = 0.420). The odds for being compliant were 1.363 times higher if the SWN-K score increased by 20 points. Changes in positive symptoms (OR = 0.773) and changes in extrapyramidal symptoms (OR = 0.830) were found to be associated with compliance. CONCLUSION: Compliance with antipsychotic medication was strongly associated with subjective well-being; further factors were clinical symptoms and side effects.
机译：目的：主观幸福被认为对抗精神病药物治疗的依从性很重要。这项对精神分裂症门诊患者健康结果研究中德国患者数据的事后分析的目的是，在诊断为精神分裂症的门诊患者中，考虑临床症状和副作用，调查主观幸福感和依从性。方法：在一项多中心观察性研究中，对2001年1月至2001年12月间招募的2960名DSM-IV定义的精神分裂症患者进行了主观幸福感测评，方法为短版（NSN-K）。 ）。依从性是自我评估和医师评估的。通过逻辑回归评估依从性与临床参数的相关性。结果：因素分析得出3个因素：SWN-K（r2 = 0.867），临床症状（r2 = 0.744）和副作用（r2 = 0.420）。如果SWN-K得分提高20分，则合规的几率是1.363倍。发现阳性症状的变化（OR = 0.773）和锥体束外症状的变化（OR = 0.830）与依从性相关。结论：抗精神病药物的依从性与主观幸福感密切相关。其他因素是临床症状和副作用。

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