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首页> 外文期刊>The journal of clinical psychiatry >Impact of severity of substance use disorder on symptomatic and functional outcome in young individuals with first-episode psychosis.
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Impact of severity of substance use disorder on symptomatic and functional outcome in young individuals with first-episode psychosis.

机译：药物滥用障碍的严重程度对首发精神病患者的症状和功能结局的影响。

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OBJECTIVE: To investigate whether severity of substance use disorder is independently associated with 15-month symptomatic or functional outcome in young individuals with first-episode psychosis. METHOD: Ninety-two individuals aged 15 to 30 years with first-episode psychosis participated in a 15-month prospective follow-up study. DSM-IV criteria were used to diagnose psychotic disorders, and DSM-III-R criteria were used to diagnose substance use disorder (abuse or dependence). Measures of outcome included severity of positive and negative symptoms, quality of life, and level of social functioning. Data were collected between March and July 2001 at a specialist first-episode psychosis service and between January and December 1997 at 2 generic mental health services. RESULTS: Multiple linear regression showed that heavy substance use disorder was significantly associated with more severe positive symptoms at 15 months after controlling for the effects of gender, duration of untreated psychosis, and medication adherence (vs. no substance use disorder, p = .006; vs. mild substance use disorder, p = .023). Heavy substance use disorder was also significantly associated with poorer social functioning at 15 months after controlling for the effects of gender, duration of untreated psychosis, medication adherence, and positive symptoms (vs. no substance use disorder, p = .025; vs. mild substance use disorder, p = .047). Heavy substance use disorder was not associated with negative symptoms or quality of life after controlling for the effects of potential confounding variables. CONCLUSION: Heavy but not mild substance use disorder appears to be independently associated with poorer symptomatic and functional outcome in young patients with first-episode psychosis.
机译：目的：调查在首次发作的精神病患者中，药物滥用障碍的严重程度是否与15个月的症状或功能结局独立相关。方法：92名年龄在15至30岁的首发精神病患者参加了为期15个月的前瞻性随访研究。 DSM-IV标准用于诊断精神病，DSM-III-R标准用于诊断药物滥用（滥用或依赖）。结果的度量包括阳性和阴性症状的严重程度，生活质量和社会功能水平。于2001年3月至7月期间在专业的第一期精神病服务中心以及1997年1月至12月之间在2家普通精神卫生服务中心收集了数据。结果：多元线性回归分析显示，在控制性别，未治疗的精神病持续时间和药物依从性的影响后，重度药物滥用症与15个月后的更严重阳性症状显着相关（与无药物滥用症相比，p = .006） ;与轻度药物滥用症相比，p = .023）。在控制了性别，未治疗的精神病的持续时间，药物依从性和阳性症状的影响后的15个月内，重度物质使用障碍也与较差的社交功能显着相关（vs.无物质使用障碍，p = .025;轻度）物质使用障碍，p = .047）。在控制了潜在混杂变量的影响之后，重物质使用障碍与阴性症状或生活质量无关。结论：重度但不是轻度的物质使用障碍似乎与年轻的首发性精神病患者较弱的症状和功能结果相关。

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